1-Naphthyl PP1 hydrochloride
Based on 3 publication(s) in Google Scholar
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 956025-47-1
- Formula: C19H20ClN5
- Molecular Weight:353.85
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 1-Naphthyl PP1 hydrochloride
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Biological Activity
1-Naphthyl PP1 hydrochloride inhibits PKD1, 2, and 3 with IC50s of 154.6 nM, 133.4 nM, 109.4 nM respectively[2].
1-Naphthyl PP1 hydrochloride (0-70 μM, 45 min) inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced autophosphorylation at p-Ser916-PKD1 in LNCaP cells with an IC50 of 22.5 µM[2].
1-Naphthyl PP1 hydrochloride (0-100 μM, 72 h) inhibits PC3 cell proliferation, survival, and arrested cells in G2/M (10 μM, 48 h)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PKCε (AS-PKCε) mice
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Dosage:30 mg/kg
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Administration:i.p.
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Result:Reversibly reduced ethanol consumption by ATP analog-specific PKCε (AS-PKCε) mice.
Chemical Information
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CAS No. 956025-47-1
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Appearance Solid
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Molecular Weight 353.85
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Formula C19H20ClN5
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Color Light yellow to khaki
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SMILES
CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C.[H]Cl
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Synonyms
1-NA-PP 1 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Plants
2026 Mar;12(3):635-652. PMID: 41644634 -
Plant J
A Förster resonance energy transfer sensor for live-cell imaging of mitogen-activated protein kinase activity in Arabidopsis. [Abstract]2019 Mar;97(5):970-983. PMID: 30444549 -
Int J Mol Sci
Fluoxetine Repurposing Mitigates Alzheimer's Disease Pathology via the GSK3β-CREB-ADAM10 Axis. [Abstract]2026 Mar 14;27(6):2676. PMID: 41898539
Solvent & Solubility
DMSO : 100 mg/mL (282.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401. [Content Brief]
[2]. Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601. [Content Brief]
[3]. Maiya R, et al. Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology. 2016 Aug;107:40-48. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8261 mL | 14.1303 mL | 28.2606 mL | 70.6514 mL |
| 5 mM | 0.5652 mL | 2.8261 mL | 5.6521 mL | 14.1303 mL | |
| 10 mM | 0.2826 mL | 1.4130 mL | 2.8261 mL | 7.0651 mL | |
| 15 mM | 0.1884 mL | 0.9420 mL | 1.8840 mL | 4.7101 mL | |
| 20 mM | 0.1413 mL | 0.7065 mL | 1.4130 mL | 3.5326 mL | |
| 25 mM | 0.1130 mL | 0.5652 mL | 1.1304 mL | 2.8261 mL | |
| 30 mM | 0.0942 mL | 0.4710 mL | 0.9420 mL | 2.3550 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7065 mL | 1.7663 mL | |
| 50 mM | 0.0565 mL | 0.2826 mL | 0.5652 mL | 1.4130 mL | |
| 60 mM | 0.0471 mL | 0.2355 mL | 0.4710 mL | 1.1775 mL | |
| 80 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8831 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2826 mL | 0.7065 mL |
1-Naphthyl PP1 hydrochloride Related Classifications
HY-13941B Related Classifications
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