1. Protein Tyrosine Kinase/RTK
  2. Src

1-Naphthyl PP1 hydrochloride (Synonyms: 1-NA-PP 1 hydrochloride)

Cat. No.: HY-13941B Purity: 99.45%
Handling Instructions

1-Naphthyl PP1(1-NA-PP1) hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).

For research use only. We do not sell to patients.

1-Naphthyl PP1 hydrochloride Chemical Structure

1-Naphthyl PP1 hydrochloride Chemical Structure

CAS No. : 956025-47-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 158 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 637 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1080 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of 1-Naphthyl PP1 hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

1-Naphthyl PP1(1-NA-PP1) hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). IC50 Value:1.0 uM (v-Src); 0.6 uM (c-Fyn); 18 uM (c-Abl) [1] Target: Src Family kinase 1-NA-PP1 was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. 1-NA-PP1 was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest. Overexpression of PKD1 or PKD3 almost completely reversed the growth arrest and the inhibition of tumor cell invasion caused by 1-NA-PP1, indicating that its anti-proliferative and anti-invasive activities were mediated through the inhibition of PKD. Interestingly, a 12-fold increase in sensitivity to 1-NA-PP1 could be achieved by engineering a gatekeeper mutation in the active site of PKD1, suggesting that 1-NA-PP1 could be paired with the analog-sensitive PKD1(M659G) for dissecting PKD-specific functions and signaling pathways in various biological systems [2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.8261 mL 14.1303 mL 28.2606 mL
5 mM 0.5652 mL 2.8261 mL 5.6521 mL
10 mM 0.2826 mL 1.4130 mL 2.8261 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

353.85

Formula

C₁₉H₂₀ClN₅

CAS No.

956025-47-1

SMILES

CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 73 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
1-Naphthyl PP1 hydrochloride
Cat. No.:
HY-13941B
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