NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)

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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a K_i of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC₅₀=0.8 nM) and recruit β-arrestin2 (EC₅₀=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects.

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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) 화학구조

CAS No. : 2891469-80-8

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제품 설명	NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a K_i of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC₅₀=0.8 nM) and recruit β-arrestin2 (EC₅₀=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects^[1].
IC₅₀ & Target	APJ^[1]
분자량	1020.18
화학식	C₄₉H₇₃N₁₃O₁₁
CAS No.	2891469-80-8
SMILES	N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=C4C=CC=CC4=CC=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
선적	Room temperature in continental US; may vary elsewhere.
보관	Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551. [Content Brief]

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Related Classifications

Cardiovascular Disease

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Keywords:

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)2891469-80-8Apelin Receptor (APJ)APJGαi1β-arrestin2cardiac effectInhibitorinhibitorinhibit

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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)

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