2891469-80-8
![NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p3346.gif "NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Chemical Structure")
2891469-80-8
Chemical Structure
NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
- CAS No.: 2891469-80-8
- Formula:C49H73N13O11
- Molecular Weight:1020.18
InChIKey: VXVNSDXGZQXERO-NXDMJTDOSA-N
SMILES: N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=C4C=CC=CC4=CC=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
Biological Activity: NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects[1].
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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) | NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects. | |||||||||||||||||||||
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References
Keywords
