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Cat. No.: HY-183906

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GSK3491943

GSK3491943 is an antagonist of the transient receptor potential vanilloid subtype 4 (TRPV4) ion channel. GSK3491943 is applicable to research related to pulmonary edema induced by heart failure.

For research use only. We do not sell to patients.

CAS No.: 2215853-96-4
Formula: C₁₈H₁₆Cl₂N₂O₅S
Molecular Weight:443.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

GSK3491943 Chemical Structure

CAS No.: 2215853-96-4

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Fluorescent Dye

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Biological Activity

Description

GSK3491943 is an antagonist of the transient receptor potential vanilloid subtype 4 (TRPV4) ion channel. GSK3491943 is applicable to research related to pulmonary edema induced by heart failure^[1].

All TRP Channel Isoforms :

Chemical Information

CAS No. 2215853-96-4
Molecular Weight 443.30
Formula C₁₈H₁₆Cl₂N₂O₅S
SMILES

OC[C@](O)(CN(C1)S(=O)(C2=C(C=C(C=C2)C#N)Cl)=O)[C@H]1OC3=CC=C(C=C3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patterson JR, et al. Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions. J Med Chem. 2020;63(23):14867-14884. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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GSK3491943

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GSK3491943 Related Classifications

HY-183906 Related Classifications