1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. DMCM hydrochloride

DMCM hydrochloride 

Cat. No.: HY-100369A Purity: 98.14%
Handling Instructions

DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5  receptors, respectively.

For research use only. We do not sell to patients.

DMCM hydrochloride Chemical Structure

DMCM hydrochloride Chemical Structure

CAS No. : 1215833-62-7

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 396 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5  receptors, respectively[1].

IC50 & Target

Ki: 10 nM (GABAA α1  receptor), 13 nM (GABAA α2 receptor), 7.5 nM (GABAA α3 receptor), 2.2 nM (GABAA α5  receptor)[1]

In Vivo

DMCM has potent convulsant, proconvulsant and anxiogenic properties in vivo. DMCM (20-60 mg/kg; i.p.) produces modest anxiolytic-like effects in γ2I77 mice[2].

Animal Model: Male γ2I77 mice[2]
Dosage: 20 mg/kg and 60 mg/kg
Administration: Injected i.p.
Result: Produced modest anxiolytic-like effects.
Molecular Weight

350.80

Formula

C₁₇H₁₉ClN₂O₄

CAS No.

1215833-62-7

SMILES

O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (71.27 mM; Need ultrasonic)

DMSO : 10 mg/mL (28.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8506 mL 14.2531 mL 28.5063 mL
5 mM 0.5701 mL 2.8506 mL 5.7013 mL
10 mM 0.2851 mL 1.4253 mL 2.8506 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DMCMGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorfullinverseagonistbenzodiazepineGABAAαxβ3γ2receptorsubtypesInhibitorinhibitorinhibit

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Product Name:
DMCM hydrochloride
Cat. No.:
HY-100369A
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