Cortistatin-29 (rat)
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
For research use only. We do not sell to patients.
- CAS No.: 1815618-17-7
- Formula: C161H240N46O41S2
- Molecular Weight:3540.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SSTR1 2.8 nM (IC50) |
SSTR2 7.1 nM (IC50) |
SSTR3 0.2 nM (IC50) |
SSTR4 3.0 nM (IC50) |
SSTR5 13.7 nM (IC50) |
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-24 g body weight, 8-12 weeks-old mice[1]
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Dosage:1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
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Administration:Every other day for 12 days
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Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
Chemical Information
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CAS No. 1815618-17-7
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Molecular Weight 3540.04
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Formula C161H240N46O41S2
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Sequence
{Glp}-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (disulfide bridge: Cys17-Cys28)
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Sequence Shortening
{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK (disulfide bridge: Cys17-Cys28)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13(7):947. [Content Brief]
[2]. Baranowska B, et al. Direct effect of cortistatin on GH release from cultured pituitary cells in the rat. Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):153-6. [Content Brief]
[3]. Spier AD, et al. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev. 2000 Sep;33(2-3):228-41. [Content Brief]
[4]. Benitez R, et al. Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury. Br J Pharmacol. 2022 May;179(10):2275-2296. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cortistatin-29 (rat) Related Classifications
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