Cortistatin-29 (rat)
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
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- CAS No.: 1815618-17-7
- Formule: C161H240N46O41S2
- Masse moléculaire:3540.04
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-142123
Fluocortolone -
HY-142123R
Fluocortolone (Standard) -
HY-16381
Pasireotide -
HY-P1932
Cortistatin-14 -
HY-111615
J-2156 -
HY-P1202
CYN 154806 -
HY-102037
SSTR5 antagonist 1 -
HY-105172
TT-232 -
HY-16381A
Pasireotide acetate -
HY-108498
L-817818 -
HY-108501
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 -
HY-79136
Pasireotide L-aspartate salt
Activité biologique
Description
IC50 & Target
[3]|
SSTR1 2.8 nM (IC50) |
SSTR2 7.1 nM (IC50) |
SSTR3 0.2 nM (IC50) |
SSTR4 3.0 nM (IC50) |
SSTR5 13.7 nM (IC50) |
In Vivo
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-24 g body weight, 8-12 weeks-old mice[1]
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Dosage:1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
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Administration:Every other day for 12 days
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Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
Chemical Information
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CAS No. 1815618-17-7
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Masse moléculaire 3540.04
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Formule C161H240N46O41S2
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Sequence
{Glp}-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (disulfide bridge: Cys17-Cys28)
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Sequence Shortening
{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK (disulfide bridge: Cys17-Cys28)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13(7):947. [Content Brief]
[2]. Baranowska B, et al. Direct effect of cortistatin on GH release from cultured pituitary cells in the rat. Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):153-6. [Content Brief]
[3]. Spier AD, et al. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev. 2000 Sep;33(2-3):228-41. [Content Brief]
[4]. Benitez R, et al. Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury. Br J Pharmacol. 2022 May;179(10):2275-2296. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cortistatin-29 (rat) Related Classifications
HY-P2150 Related Classifications
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