1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
  3. J-2156

J-2156 

Cat. No.: HY-111615
Handling Instructions

J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively.

For research use only. We do not sell to patients.

J-2156 Chemical Structure

J-2156 Chemical Structure

CAS No. : 848647-56-3

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Description

J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively[1].

IC50 & Target

IC50: 0.05 nM (human SST4) and 0.07 nM (rat SST4)[1]

In Vivo

J-2156 (1-10 mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1].

Animal Model: BCIBP-rats[1]
Dosage: 1, 3, 10 mg/kg
Administration: I.p.; for 3 hours
Result: Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.
Molecular Weight

468.57

Formula

C₂₄H₂₈N₄O₄S

CAS No.

848647-56-3

SMILES

O=C(N)[[email protected]@H](NC([[email protected]](CCN)NS(C1=CC=C(C)C2=CC=CC=C21)(=O)=O)=O)CC3=CC=CC=C3

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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