2. Inhibitory Antibodies
  3. KY-1044

KY-1044  (Synonyms: Alomfilimab; SAR 445256)

Cat. No.: HY-P99431 Purity: 99.51%
COA

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KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

For research use only. We do not sell to patients.

KY-1044 Chemical Structure

KY-1044 Chemical Structure

CAS No. : 2489390-15-8

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Description

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

In Vitro

KY-1044 (Alomfilimab; SAR 445256; 0-100ng/mL; 4 hours) causes human natural killer (NK) cells expressing hICOS (5:1 effector:target cell ratio) to induce potent ADCC-mediated killing (EC50=5.6 pmol/L)[1].
KY-1044 significantly induces the luciferase signal (EC50 of 0.15 nmol/L). A similar EC50 is obtained against mouse ICOS (0.53 nmol/L), rat ICOS (0.48 nmol/L), or cynomolgus monkey ICOS (0.22 nmol/L)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KY-1044 Related Antibodies
In Vivo

KY-1044 (Alomfilimab; SAR 445256; 10 mg/kg; ip; twice a week for 3 weeks) mIgG2a (effector enable) monotherapy blocks tumor growth in lymphoma/myeloma tumor models[1].
In syngeneic mouse tumor models, KY-1044 depletes ICOShigh Treg and increases the intratumoral TEff:Treg ratio, resulting in increased secretion of IFNγ and TNFα by TEff cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-week-old wild-type female Balb/C or C57BL/6J mice with A20 cells[1]
Dosage: 200 μg (10 mg/kg)
Administration: IP; twice a week for 3 weeks starting from 6 days following tumor cell implantation
Result: Triggered an antitumor response, with more than 90% of the mice being free from measurable disease at the end of the study (day 42).
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[KY-1044]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.51%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY-10442489390-15-8Alomfilimab SAR 445256KY1044KY 1044SAR445256SAR 445256SAR-445256OthersHumanIgG1antibodyinducible costimulatory receptorICOSantibody-dependent cellular cytotoxicityADCCFcgRIIIaCD8+ TEff cellsFcgRimmune responseInhibitorinhibitorinhibit

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