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KY-1044

(Synonyms: Alomfilimab; SAR 445256)
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Based on 1 Customer Validation

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

For research use only. We do not sell to patients.

  • Purity: 99.51%
  • CAS No.: 2489390-15-8
  • Molecular Weight:146.5 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • KY-1044 Chemical Structure
    KY-1044 Chemical Structure
CAS No.: 2489390-15-8
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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KY-1044 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.

  • 1/16

    Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).

  • KY-1044 Chemical Structure
    1/16
  • KY-1044
  • Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.
  • Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).