ICOS - inducible T cell costimulator Gene

Homo sapiens

Also known as AILIM; CD278; CVID1

Gene ID: 29851 | Gene type: protein coding

About ICOS

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,936,763-203,961,577 (from NCBI)

This gene has 2 transcripts (splice variants), 115 orthologues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 7.8), bone marrow (RPKM 6.5) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS Products(1)

mRNA	Protein	Name
NM_012092.4	NP_036224.1	inducible T-cell costimulator precursor

Protein Preferred Names

Protein Names

inducible T-cell costimulator

activation-inducible lymphocyte immunomediatory molecule

Recombinant ICOS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7587	Recombinant Human ICOS Protein (CHO-expressed)	Q9Y6W8	/
HY-P72618	ICOS Protein, Human (121a.a, HEK293, Fc)	Q9Y6W8 (E21-F141)	≥95%
HY-P76395	ICOS Protein, Human (141a.a, HEK293, Fc)	Q9Y6W8 (M1-F141)	≥95%
HY-P76396	ICOS Protein, Human (HEK293, His-Fc)	Q9Y6W8 (M1-F141)	≥95%
HY-P78546	ICOS Protein, Human (C136S, C137S, HEK293, His)	Q9Y6W8 (E21-F141, C136S, C137S)	≥95%
HY-P78864	ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi )	Q9Y6W8 (E21-F141, C136S, C137S)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency, Common Variable, 1

CVID1	Antibody Deficiency Due To Icos Defect
Icos Deficiency	Common Variable Immunodeficiency 1
Immunodeficiency, Variable, Common, Type 1

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency, Common Variable, 2

CVID2	Antibody Deficiency Due To Taci Defect
Hypogammaglobulinemia Due To Taci Deficiency	Common Variable Immunodeficiency 2
Immunodeficiency, Variable, Common, Type 2

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P99474	Bertilimumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06520	ICOS Human Pre-designed siRNA Set A		/	Unkown
HY-W011267	(Z)-Methyl icos-11-enoate		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99679	Izuralimab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ICOS	RGD	RGD:620123
Canis familiaris	ICOS	VGNC	VGNC:41861
Mus musculus	ICOS	MGD	MGI:1858745
Macaca mulatta	ICOS	VGNC	VGNC:73555
Bos taurus	ICOS	VGNC	VGNC:30030
Felis catus	ICOS	VGNC	VGNC:80240
Macaca fascicularis	ICOS	NCBI
Others	ICOS	NCBI

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