ICOS - inducible T cell costimulator Gene

Also Known as AILIM; CD278; CVID1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29851

About ICOS

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,936,763-203,961,577 (from NCBI)

This gene has 2 transcripts (splice variants), 115 orthologues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 7.8), bone marrow (RPKM 6.5) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS Products (1)

mRNA	Protein	Name
NM_012092.4	NP_036224.1	inducible T-cell costimulator precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11956294	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
inducible T-cell costimulator	activation-inducible lymphocyte immunomediatory molecule

ICOS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	ELISA	11956294
Intra	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	SPR	11956294
Intra	ICOS	Q9Y6W8	ICOSLG	Homo sapiens	O75144	Far-WB	16951355
Intra	ICOS	Q9Y6W8	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	27135603
Intra	ICOS	Q9Y6W8	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	18641334
Intra	ICOS	Q9Y6W8	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	27135603

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ICOS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72618	ICOS Protein, Human (HEK293, Fc)	Q9Y6W8-1 (E21-F141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76396	ICOS Protein, Human (HEK293, His-Fc)	Q9Y6W8-1 (E21-F141)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78546	ICOS Protein, Human (C136S, C137S, HEK293, His)	Q9Y6W8-1 (E21-F141, C136S, C137S)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78864	ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi )	Q9Y6W8-1 (E21-F141, C136S, C137S)	≥ 90%, as determined by reducing SDS-PAGE.

ICOS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81467	ICOS Antibody (YA1212)	IHC-P	Human
HY-P81467A	ICOS Antibody (YA1212)(PBS only)	IHC-P	Human
HY-P84984	ICOS Antibody (YA4676)	ELISA	Human
HY-P86912	ICOS Antibody (YA6605)	WB	Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 1	CVID1 Antibody Deficiency Due To Icos Defect Icos Deficiency Common Variable Immunodeficiency 1 Immunodeficiency, Variable, Common, Type 1
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immunodeficiency, Common Variable, 2	CVID2 Antibody Deficiency Due To Taci Defect Hypogammaglobulinemia Due To Taci Deficiency Common Variable Immunodeficiency 2 Immunodeficiency, Variable, Common, Type 2
Dermatitis, Atopic, 5	ATOD5 Atopic Dermatitis 5 Dermatitis, Atopic, Susceptibility To, 5 Dermatitis, Atopic 5
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99363	Feladilimab		99.255%	Phase 3
HY-P99414	Prezalumab	Inhibitor	99.41%	Phase 2
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P99474	Bertilimumab	Inhibitor	97.01%	Phase 2
HY-P99431	KY-1044		99.51%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150743	ODN 2395	Agonist	98.39%	Unkown
HY-159692	AZD8701	Inhibitor	96.61%	Unkown
HY-W011267	(Z)-Methyl icos-11-enoate		98.02%	Unkown
HY-162810	ICOS-IN-1		/	Unkown
HY-RS06520	ICOS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W011267R	(Z)-Methyl icos-11-enoate (Standard)		/	Unkown
HY-166209	Ethyl 8(Z)-eicosenoate		/	Unkown
HY-184441	CD28-IN-4	Inhibitor	/	Unkown
HY-RS16819	Icos Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23260	Icos Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990236	Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Inhibitor	98.81%	Unkown
HY-P990237	Anti-Mouse ICOS Antibody (7E.17G9)	Inhibitor	98%	Unkown
HY-P99679	Izuralimab	Inhibitor	99.97%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ICOS	RGD	RGD:620123
Canis familiaris	ICOS	VGNC	VGNC:41861
Mus musculus	ICOS	MGD	MGI:1858745
Macaca mulatta	ICOS	VGNC	VGNC:73555
Bos taurus	ICOS	VGNC	VGNC:30030
Felis catus	ICOS	VGNC	VGNC:80240
Others	ICOS	NCBI