2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. ICOS Antibody (YA1212)

ICOS Antibody (YA1212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICOS.

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Tamaño Precio Stock Cantidad
20 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Obtener un presupuesto  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

  • Referencias

Descripciòn

ICOS Antibody (YA1212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICOS.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Peso molecular
Predicted band size: 23 kDa;
Observed band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human ICOS
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.309.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:9930702). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:33033255). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:27135603). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:30523347). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted
Expression：
Tissue_specificity:Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

Induction:By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation
Isoforms & Post-Translational Modification：Q9Y6W8 has 2 isomers: Q9Y6W8-1: 22625 Da (predicted); Q9Y6W8-2: 19127 Da (predicted).
N-glycosylated
Subunit：Homodimer; disulfide-linked. Interacts with ICOSLG (PubMed:33033255). Interacts with PIK3R1 (PubMed:30523347). Interacts with TBK1; this interaction is critical for the maturation of T follicular regulatory cells (PubMed:27135603)
Database

Entrez Gene: 29851 Human

SwissProt: Q9Y6W8 Human

OMIM: 607594 Human

Research Field

Immunology
Synonyms
ICOS; AILIM; CD278; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule
Documentación
User Guide for Antibodies (1077 KB)
Referencias

ICOS Antibody (YA1212) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
ICOS Antibody (YA1212)
Cat. No.:
HY-P81467
Cantidad:
MCE Japan Authorized Agent:

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