Anti-Mouse ICOS Antibody (7E.17G9)
Based on 1 Customer Validation
Anti-Mouse ICOS Antibody (7E.17G9) is a mouse ICOS agonist IgG2b monoclonal antibody. Anti-Mouse ICOS Antibody (7E.17G9) can upregulate ICOS expression and enhance T cell function. Anti-Mouse ICOS Antibody (7E.17G9) can significantly inhibit the immune regulatory function of dendritic cells (DCs). Anti-Mouse ICOS Antibody (7E.17G9) can eliminate transplant tolerance. Anti-Mouse ICOS Antibody (7E.17G9) can be used for researches on inflammation conditions, cancer and xenotransplantation such as nephritis and pancreatic cancer.
For research use only. We do not sell to patients.
- Purity : 98%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
ICOS
In Vitro
In Vivo
Anti-Mouse ICOS Antibody (7E.17G9) (0.2 mg, i.p., once every other day, from day 13 to day 25) significantly inhibits the induction of IL-10+ Tregs in C57BL/6 mice with a MPO immune model[2].
Anti-Mouse ICOS Antibody (7E.17G9) (100 μg, i.p., on day 4, 7 and 10) significantly prolongs the survival period of C57BL/6 mice bearing KPC tumors combined with RIP1i[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PD-1 Tg B6 mice (8-12 weeks)[1]
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Dosage:375 μg on day 0, 250 μg on day 2, 4 and 6
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Administration:Intraperitoneal injection (i.p.), on day 0, 2, 4 and 6
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Result:Significantly shortened the survival time of transplants.
Slightly increased the production of IFN-γ, but significantly reduced the production of IL-10.
Reduced IL-10 production and LAP expression in Treg cells.
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Animal Model:MPO (20 μg) and CFA (HY-153808) injected C57BL/6 mice (8-12 weeks)[2]
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Dosage:0.2 mg
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Administration:Intraperitoneal injection (i.p.), once every other day, from day 13 to day 25
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Result:Significantly inhibited the induction of IL-10+ Tregs by MPO/BAY DCs.
Inhibited the upregulation of Foxp3, CTLA4 and TNFR2.
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Animal Model:1×105 KPC cells injected C57BL/6 mice (8-10 weeks)[3]
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Dosage:100 μg, combined with RIP1i (100 mg/kg)
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Administration:Intraperitoneal injection (i.p.), on day 4, 7 and 10
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Result:Upregulated ICOS expression and enhances T cell function. Significantly prolonged the survival period of mice.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo blocking of ICOS/ICOSL signaling; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse ICOS Antibody (7E.17G9)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Borges TJ, et al. Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms. JCI Insight. 2021 Dec 22;6(24):e142909. [Content Brief]
[2]. Odobasic D, et al. Tolerogenic Dendritic Cells Attenuate Experimental Autoimmune Antimyeloperoxidase Glomerulonephritis. J Am Soc Nephrol. 2019 Nov;30(11):2140-2157. [Content Brief]
[3]. Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34(5):757-774.e7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse ICOS Antibody (7E.17G9) Related Classifications
HY-P990237 Related Classifications
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