Icos - inducible T cell co-stimulator Gene

Also Known as H4; CCLP; AILIM; CRP-1; Ly115

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54167

Summary

Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Is integral component of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]

Icos Products (1)

mRNA Protein Name
NM_017480.2 NP_059508.2 inducible T-cell costimulator precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10657606 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
10760791 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10760791 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inducible T-cell costimulator

  • CD28 and CTLA-4-like protein

  • CD28-related protein 1

  • activation-inducible lymphocyte immunomediatory molecule

Icos Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Icos Q9WVS0 Pik3r1 Mus musculus P26450
Anti Bait CoIP
27135603
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Icos Proteins

Cat. No. Product Name Accession Purity
HY-P72619 ICOS Protein, Mouse (HEK293, His) Q9WVS0 (E21-L142) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76397 ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Q9WVS0 (E21-L144) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78306 ICOS Protein, Mouse (C137S, C138S, HEK293, His) Q9WVS0 (E21-L144, C137S, C138S) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78307 ICOS Protein, Mouse (HEK293, Fc) Q9WVS0 (E21-L144) ≥ 90%, as determined by SDS-PAGE or Bis-Tris PAGE.
HY-P78673 ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) Q9WVS0 (E21-L144, C137S, C138S) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99363 Feladilimab 99.255% Phase 3
HY-P99414 Prezalumab Inhibitor 99.41% Phase 2
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P99474 Bertilimumab Inhibitor 97.01% Phase 2
HY-P99431 KY-1044 99.51% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150743 ODN 2395 Agonist 98.39% Unkown
HY-159692 AZD8701 Inhibitor 96.61% Unkown
HY-W011267 (Z)-Methyl icos-11-enoate 98.02% Unkown
HY-162810 ICOS-IN-1 / Unkown
HY-RS06520 ICOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011267R (Z)-Methyl icos-11-enoate (Standard) / Unkown
HY-166209 Ethyl 8(Z)-eicosenoate / Unkown
HY-184441 CD28-IN-4 Inhibitor / Unkown
HY-RS16819 Icos Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23260 Icos Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990236 Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) Inhibitor 98.81% Unkown
HY-P990237 Anti-Mouse ICOS Antibody (7E.17G9) Inhibitor 98% Unkown
HY-P99679 Izuralimab Inhibitor 99.97% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Icos NCBI NCBI:29851