ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi)

ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is 142 a.a., with molecular weight of ~42.4 KDa.

The ICOS protein enhances all fundamental T-cell responses to foreign antigens, including proliferation, secretion of lymphokines, up-regulation of cell-cell interaction molecules, and providing effective help for antibody secretion by B-cells. It is essential for facilitating efficient communication between T and B-cells and for normal antibody responses to T-cell dependent antigens. Although it does not increase the production of interleukin-2, it superinduces the synthesis of interleukin-10. Additionally, it prevents apoptosis of pre-activated T-cells and plays a critical role in CD40-mediated class switching of immunoglobulin isotypes. ICOS exists as a homodimer, connected by disulfide bonds.

Mouse

HEK293

C-Avi;C-hFc

Q9WVS0 (M1-L142)

54167  [NCBI]

Approximately 42.4 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.