Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)
Based on 1 Customer Validation
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .
For research use only. We do not sell to patients.
- Purity : 98.81%
- Molecular Weight:146.002 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Human/Mouse/Rat/Monkey
IC50 & Target
ICOS/CD278
In Vitro
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) (5 μg/mL, 4 days) fails to significantly increase the production of IFNγ in splenocytes from glioma-bearing mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HBV transgenic mice (8-10 weeks)[2]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), single dose, 24 h after T cell transplantation
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Result:Failed to significantly reduce HBV replication.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vitro T cell stimulation/activation; Flow cytometry; Immunoprecipitation
Chemical Information
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Appearance Liquid
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Molecular Weight 146.002 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Belcaid Z, et al. Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy. Neurooncol Adv. 2020 Feb 3;2(1):vdaa011. [Content Brief]
[2]. Andreata F, et al. Therapeutic potential of co-signaling receptor modulation in hepatitis B. Cell. 2024 Jul 25;187(15):4078-4094.e21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) Related Classifications
HY-P990236 Related Classifications
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