Fluphenazine-d8 dihydrochloride
Based on 1 Customer Validation
Fluphenazine-d8 (dihydrochloride) is the deuterium labeled Fluphenazine dihydrochloride. Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.
For research use only. We do not sell to patients.
- Purity: 99.27%
- Formula: C22H20D8Cl2F3N3OS
- Molecular Weight:518.49
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 146-56-5
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Appearance Solid
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Molecular Weight 518.49
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Formula C22H20D8Cl2F3N3OS
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Color White to off-white
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SMILES
FC(C1=CC=C2SC3=C(C=CC=C3)N(C2=C1)CCCN4C([2H])(C([2H])(N(CCO)C([2H])(C4([2H])[2H])[2H])[2H])[2H])(F)F.[2HCl]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (192.87 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (584 KB)
- English - EN (584 KB)
- Français - FR (584 KB)
- Deutsch - DE (584 KB)
- Norwegian - NO (584 KB)
- Español - ES (584 KB)
- Swedish - SV (584 KB)
- Italian - IT (584 KB)
- Korean - KR (584 KB)
- Portuguese - PT (584 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700. [Content Brief]
[3]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73. [Content Brief]
[4]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.9287 mL | 9.6434 mL | 19.2868 mL | 48.2169 mL |
| 5 mM | 0.3857 mL | 1.9287 mL | 3.8574 mL | 9.6434 mL | |
| 10 mM | 0.1929 mL | 0.9643 mL | 1.9287 mL | 4.8217 mL | |
| 15 mM | 0.1286 mL | 0.6429 mL | 1.2858 mL | 3.2145 mL | |
| 20 mM | 0.0964 mL | 0.4822 mL | 0.9643 mL | 2.4108 mL | |
| 25 mM | 0.0771 mL | 0.3857 mL | 0.7715 mL | 1.9287 mL | |
| 30 mM | 0.0643 mL | 0.3214 mL | 0.6429 mL | 1.6072 mL | |
| 40 mM | 0.0482 mL | 0.2411 mL | 0.4822 mL | 1.2054 mL | |
| 50 mM | 0.0386 mL | 0.1929 mL | 0.3857 mL | 0.9643 mL | |
| 60 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8036 mL | |
| 80 mM | 0.0241 mL | 0.1205 mL | 0.2411 mL | 0.6027 mL | |
| 100 mM | 0.0193 mL | 0.0964 mL | 0.1929 mL | 0.4822 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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