Terbuthylazine-d5
Based on 1 Customer Validation
Terbuthylazine-d5 is the deuterium labeled Terbuthylazine (HY-B1847). Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein.
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- Purity : 99.13%
- CAS No.: 222986-60-9
- 화학식: C9H11D5ClN5
- 분자량:234.74
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 222986-60-9
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Unlabeled CAS 5915-41-3
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Appearance Solid
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분자량 234.74
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화학식 C9H11D5ClN5
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Color White to off-white
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SMILES
CC(C)(C)NC1=NC(Cl)=NC(NC([2H])([2H])C([2H])([2H])[2H])=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : ≥ 30 mg/mL (127.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 30 mg/mL (127.80 mM)
Ethanol : ≥ 1 mg/mL (4.26 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Cedergreen N, et al. Does the effect of herbicide pulse exposure on aquatic plants depend on Kow or mode of action? Aquat Toxicol. 2005 Feb 10;71(3):261-271. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 4.2600 mL | 21.3002 mL | 42.6003 mL | 106.5008 mL |
| DMSO / DMF | 5 mM | 0.8520 mL | 4.2600 mL | 8.5201 mL | 21.3002 mL |
| 10 mM | 0.4260 mL | 2.1300 mL | 4.2600 mL | 10.6501 mL | |
| 15 mM | 0.2840 mL | 1.4200 mL | 2.8400 mL | 7.1001 mL | |
| 20 mM | 0.2130 mL | 1.0650 mL | 2.1300 mL | 5.3250 mL | |
| 25 mM | 0.1704 mL | 0.8520 mL | 1.7040 mL | 4.2600 mL | |
| 30 mM | 0.1420 mL | 0.7100 mL | 1.4200 mL | 3.5500 mL | |
| 40 mM | 0.1065 mL | 0.5325 mL | 1.0650 mL | 2.6625 mL | |
| 50 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1300 mL | |
| 60 mM | 0.0710 mL | 0.3550 mL | 0.7100 mL | 1.7750 mL | |
| 80 mM | 0.0533 mL | 0.2663 mL | 0.5325 mL | 1.3313 mL | |
| 100 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL |
Terbuthylazine-d5 Related Classifications
HY-B1847S1 Related Classifications
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