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Cat. No.: HY-182583

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PAF antagonist-1

PAF antagonist-1 is a platelet activating factor (PAF) receptor antagonist with a target K_i of 69 nM. PAF antagonist-1 inhibits PAF binding and displays enhanced affinity at A₁, A₂^a, and A₃ adenosine receptor subtypes compared to related dihydropyridine analogs with smaller ester groups. PAF antagonist-1 can be used for cardiovascular disorders, especially hypertension and coronary heart disease.

For research use only. We do not sell to patients.

CAS No.: 81635-83-8
Formula: C₂₀H₂₅NO₄S
Molecular Weight:375.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAF antagonist-1 Chemical Structure

CAS No.: 81635-83-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

PAF antagonist-1 (compound 4) potently inhibits PAF receptor binding with a K_i of 69 nM^[1].
PAF antagonist-1 shows no activity at rat brain membrane L-type calcium channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81635-83-8
Molecular Weight 375.48
Formula C₂₀H₂₅NO₄S
SMILES

O=C(C1=C(C)NC(C)=C(C1C)C(OCCSC2=CC=CC=C2)=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. van Rhee AM, et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. J Med Chem. 1996;39(15):2980-2989. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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