DCB-3503

Cat. No.: HY-111244: Data Sheet Handling Instructions
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DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1.

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DCB-3503 Chemical Structure

CAS No. : 87302-58-7

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human 786-O cells after 72 hrs by SRB assay Antiproliferative activity against human 786-O cells after 72 hrs by SRB assay	[PMID: 28333459]
A549	GI₅₀	0.67 μM Compound: 16, DCB-3503	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
A549	IC₅₀	0.283 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay	[PMID: 28333459]
BXPC-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB assay Antiproliferative activity against human BxPC3 cells after 72 hrs by SRB assay	[PMID: 28333459]
Bel-7402	IC₅₀	0.11 μM Compound: 1	Antiproliferative activity against human Bel7402 cells assessed as reduction in viability after 72 hrs by SRB assay Antiproliferative activity against human Bel7402 cells assessed as reduction in viability after 72 hrs by SRB assay	[PMID: 28333459]
Bel-7402	IC₅₀	0.11 μM Compound: 1; DCB-3503	Antiproliferative activity against human Bel-7402 cells after 72 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells after 72 hrs by SRB assay	[PMID: 31171403]
COLO 205	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human COLO205 cells after 72 hrs by SRB assay Antiproliferative activity against human COLO205 cells after 72 hrs by SRB assay	[PMID: 28333459]
Detroit 562	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Detroit 562 cells after 72 hrs by SRB assay Antiproliferative activity against human Detroit 562 cells after 72 hrs by SRB assay	[PMID: 28333459]
HCT-116	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 28333459]
HL-60	IC₅₀	0.213 μM Compound: 1; DCB-3503	Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 31171403]
HL-60	IC₅₀	212.8 nM Compound: 1	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	[PMID: 28333459]
HL60/MX2	IC₅₀	278.3 nM Compound: 1	Antiproliferative activity against human HL60/MX2 cells after 72 hrs by MTT assay Antiproliferative activity against human HL60/MX2 cells after 72 hrs by MTT assay	[PMID: 28333459]
HeLa	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 28333459]
Hep 3B2	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Hep3B cells after 72 hrs by SRB assay Antiproliferative activity against human Hep3B cells after 72 hrs by SRB assay	[PMID: 28333459]
HepG2	IC₅₀	1067 nM Compound: DCB-3503	Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay	[PMID: 17531481]
HepG2	IC₅₀	1067 nM Compound: DCB-3503	Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay	[PMID: 17531481]
HepG2	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay Antiproliferative activity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 28333459]
HepG2 2.2.15	IC₅₀	98.9 nM Compound: DCB-3503	Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition Cytotoxicity against human HepG2(2.2.15) cells assessed as cell growth inhibition	[PMID: 29317151]
Huh-7	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human HuH7 cells after 72 hrs by SRB assay Antiproliferative activity against human HuH7 cells after 72 hrs by SRB assay	[PMID: 28333459]
K562	IC₅₀	98.4 nM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 28333459]
K562/Adr	IC₅₀	137.5 nM Compound: 1	Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay Antiproliferative activity against human K562/ADR cells after 72 hrs by MTT assay	[PMID: 28333459]
KB	IC₅₀	58.2 nM Compound: 1	Antiproliferative activity against human KB cells after 72 hrs by SRB assay Antiproliferative activity against human KB cells after 72 hrs by SRB assay	[PMID: 28333459]
KB-V1	GI₅₀	30 nM Compound: 1	Growth inhibition of human KBV1 cells after 8 days by methylene blue-staining based spectrophotometry Growth inhibition of human KBV1 cells after 8 days by methylene blue-staining based spectrophotometry	[PMID: 28333459]
MCF7	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 28333459]
MDA-MB-157	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MDA-MB-157 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-157 cells after 72 hrs by SRB assay	[PMID: 28333459]
MDA-MB-231	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 28333459]
MKN-45	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human MKN45 cells after 72 hrs by SRB assay Antiproliferative activity against human MKN45 cells after 72 hrs by SRB assay	[PMID: 28333459]
PC-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay	[PMID: 28333459]
RAW264.7	IC₅₀	36 nM Compound: 4, DCB-3503	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 6 hrs by ELISA	[PMID: 25221661]
RAW264.7	IC₅₀	53 nM Compound: 4, DCB-3503	Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 48 hrs by MTT assay	[PMID: 25221661]
SGC-7901	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SGC7901 cells after 72 hrs by SRB assay Antiproliferative activity against human SGC7901 cells after 72 hrs by SRB assay	[PMID: 28333459]
SJRH30	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human Rh30 cells after 72 hrs by SRB assay Antiproliferative activity against human Rh30 cells after 72 hrs by SRB assay	[PMID: 28333459]
SK-HEP1	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay	[PMID: 28333459]
SK-OV-3	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SKOV3 cells after 72 hrs by SRB assay Antiproliferative activity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 28333459]
SMMC-7721	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SMMC7721 cells after 72 hrs by SRB assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by SRB assay	[PMID: 28333459]
SU-DHL-6	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human SUDHL6 cells after 72 hrs by MTT assay Antiproliferative activity against human SUDHL6 cells after 72 hrs by MTT assay	[PMID: 28333459]
Splenocyte	IC₅₀	20 nM Compound: 4, DCB-3503	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 25221661]
Splenocyte	IC₅₀	97 nM Compound: 4, DCB-3503	Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA	[PMID: 25221661]
T47D	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human T47D cells after 72 hrs by SRB assay Antiproliferative activity against human T47D cells after 72 hrs by SRB assay	[PMID: 28333459]
U-118-MG	IC₅₀	166.7 nM Compound: 1	Antiproliferative activity against human U118MG cells after 72 hrs by SRB assay Antiproliferative activity against human U118MG cells after 72 hrs by SRB assay	[PMID: 28333459]

Molecular Weight

409.47

Formula

C₂₄H₂₇NO₅

CAS No.

87302-58-7

SMILES

O[C@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70 [Content Brief]

DCB-3503 Related Classifications

Others

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCB-350387302-58-7DCB3503DCB 3503CDKHSPCyclin dependent kinaseHeat shock proteinsInhibitorinhibitorinhibit

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