87302-58-7
Chemical Structure
DCB-3503
- CAS No.: 87302-58-7
- Formula:C24H27NO5
- Molecular Weight:409.47
IUPAC Name: (13aS,14S)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinolin-14-ol
InChIKey: JWHWLMNMGLICQZ-MHECFPHRSA-N
SMILES: O[C@H]1C2=C(C=C(C(OC)=C3)OC)C3=C(C=C(C(OC)=C4)OC)C4=C2CN5[C@@]1([H])CCC5
Biological Activity: DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1[1].
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DCB-3503 | DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1. | |||||||||||||||||||||
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