CV1808  (Synonyms: 2-Phenylaminoadenosine)

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively^[1].

CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM^[1].
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC₅₀ value for CV1808 is 2 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

358.35

C₁₆H₁₈N₆O₄

53296-10-9

Solid

Off-white to light yellow

NC1=C2C(N([C@@]3([H])[C@@H]([C@@H]([C@H](O3)CO)O)O)C=N2)=NC(NC4=CC=CC=C4)=N1

Room temperature in continental US; may vary elsewhere.

• [1]. K H Yip, et al. Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors. Br J Pharmacol. 2011 Sep;164(2b):807-19.  [Content Brief]

  [2]. I van der Ploeg,et al.Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol.1996 Feb;353(3):250-60.  [Content Brief]

  [3]. Ming-Guo Feng, et al. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol. 2010 Aug;299(2):F310-5.  [Content Brief]