1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adenosine Receptor
    Endogenous Metabolite
  3. CV1808

CV1808 (Synonyms: 2-Phenylaminoadenosine)

Cat. No.: HY-103183
Handling Instructions

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.

For research use only. We do not sell to patients.

CV1808 Chemical Structure

CV1808 Chemical Structure

CAS No. : 53296-10-9

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Description

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1].
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rat, weighing 370-410 g[3]
Dosage: 0.002, 0.02, 0.2, and 2 μM
Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
Molecular Weight

358.35

Formula

C₁₆H₁₈N₆O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CV1808
Cat. No.:
HY-103183
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