1. Recombinant Proteins
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  3. HIV Proteins
  4. HIV-1 gp160
  5. envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His)

envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His)

Cat. No.: HY-P74885
Handling Instructions

gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41. envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is 464 a.a., with molecular weight of ~52.2 kDa.

For research use only. We do not sell to patients.

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Description

gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41. envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is 464 a.a., with molecular weight of ~52.2 kDa.

Background

gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursor is proteolytically cleaved in the trans-Golgi apparatus and thus activated by cellular furin or Furin-like proteases to produce surface gp120 and transmembrane protein gp41. The sequential binding of gp120 to receptors (CD4) and co-receptors (such as CCR5 or CXCR4) triggers large conformational changes in gp120 and gp41, leading to fusion and viral entry[1][2].

Species

Virus

Source

HEK293

Tag

C-His

Accession

AAT67478 (E31-R494)

Gene ID

/

Molecular Construction
N-term
HIV-1 gp160 (E31-R494)
Accession # AAT67478
His
C-term
Synonyms
HIV-1 (group M, subtype A, isolate 92RW020) Envelope glycoprotein gp160 Protein (gp120 subunit) (His)
Molecular Weight

Approximately 52.2 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His)
Cat. No.:
HY-P74885
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