envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His)

gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum.gp160 is transported in the host Golgi apparatus to complete the glycosylation process.The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41.envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag.

gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursor is proteolytically cleaved in the trans-Golgi apparatus and thus activated by cellular furin or Furin-like proteases to produce surface gp120 and transmembrane protein gp41. The sequential binding of gp120 to receptors (CD4) and co-receptors (such as CCR5 or CXCR4) triggers large conformational changes in gp120 and gp41, leading to fusion and viral entry^[1][2].

Virus

HEK293

C-His

AAT67478 (E31-R494)

/

Partial

ENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEIHLENVTEDFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLDCNATASNVTNEMRNCSFNITTELKDKKQQVYSLFYKLDVVQINEKNETDKYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDTEFNGTGPCKNVSTVQCTHGIRPVISTQLLLNGSLAEEGIQIRSENITNNAKTIIVQLDKAVKINCTRPNNNTRKGVRIGPGQAFYATGGIIGDIRQAHCNVSRAKWNDTLRGVAKKLREHFKNKTIIFEKSSGGDIEITTHSFNCGGEFFYCNTSGLFNSTWESNSTESNNTTSNDTITLTCRIKQIINMWQKVGQAMYAPPIQGVIRCESNITGLLLTRDGGNNSTNEIFRPGGGNMRDNWRSELYKYKVVKIEPLGVAPSRAKRRVVEREKR

Approximately 52.2 kDa

≥ 85%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.