envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His)
Based on 1 Customer Validation
gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum.gp160 is transported in the host Golgi apparatus to complete the glycosylation process.The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41.envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Virus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum.gp160 is transported in the host Golgi apparatus to complete the glycosylation process.The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41.envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag.
Background
gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursor is proteolytically cleaved in the trans-Golgi apparatus and thus activated by cellular furin or Furin-like proteases to produce surface gp120 and transmembrane protein gp41. The sequential binding of gp120 to receptors (CD4) and co-receptors (such as CCR5 or CXCR4) triggers large conformational changes in gp120 and gp41, leading to fusion and viral entry[1][2].
Technical Parameters
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Species Virus
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Source HEK293
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Tag C-His
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Accession
AAT67478 (E31-R494)
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Gene ID/
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Molecular Construction
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N-term
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HIV-1 gp160 (E31-R494)
Accession # AAT67478 -
His
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C-term
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Protein Length
Partial
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Synonyms
Envelope glycoprotein gp160; Env polyprotein; Surface protein gp120; SU; Glycoprotein 120; gp120; Transmembrane protein gp41; TM; Glycoprotein 41; gp41 ; env
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AA Sequence
ENLWVTVYYGVPVWKDAETTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEIHLENVTEDFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLDCNATASNVTNEMRNCSFNITTELKDKKQQVYSLFYKLDVVQINEKNETDKYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDTEFNGTGPCKNVSTVQCTHGIRPVISTQLLLNGSLAEEGIQIRSENITNNAKTIIVQLDKAVKINCTRPNNNTRKGVRIGPGQAFYATGGIIGDIRQAHCNVSRAKWNDTLRGVAKKLREHFKNKTIIFEKSSGGDIEITTHSFNCGGEFFYCNTSGLFNSTWESNSTESNNTTSNDTITLTCRIKQIINMWQKVGQAMYAPPIQGVIRCESNITGLLLTRDGGNNSTNEIFRPGGGNMRDNWRSELYKYKVVKIEPLGVAPSRAKRRVVEREKR
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Predicted Molecular Mass
52.2 kDa
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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