1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. MK-0343

MK-0343 (Synonyms: MRK-409)

Cat. No.: HY-101869
Handling Instructions

MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic.

For research use only. We do not sell to patients.

MK-0343 Chemical Structure

MK-0343 Chemical Structure

CAS No. : 233275-76-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 393 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic[1].

IC50 & Target

Ki: 0.22 nM (rGABAA α1), 0.4 nM (rGABAAα2) , 0.21 nM (rGABAAα3), 78 nM (rGABAAα4), 0.23 nM (rGABAAα5), 980 nM (rGABAAα6)[1]

In Vivo

MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [3H]flumazenil binding assay, with an Occ50 of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL[1].

Animal Model: Male Sprague-Dawley rats (approximately 250–300g) (pharmacokinetics)[1]
Dosage: 1, 2 or 3 mg/kg
Administration: Oral administration
Result: Readily penetrated the brain in rats and occupies the benzodiazepine site of GABAA receptors, with an Occ50 of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL.
Molecular Weight

397.38

Formula

C₁₉H₁₇F₂N₇O

CAS No.

233275-76-8

SMILES

CN1N=CN=C1COC2=NN3C(C=C2C4CCC4)=NN=C3C5=C(F)C=CC=C5F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MK-0343MRK-409MK0343MK 0343MRK409MRK 409GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAanxiolyticInhibitorinhibitorinhibit

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MK-0343
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HY-101869
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