1. GPCR/G Protein
  2. P2Y Receptor
  3. PSB-1114 tetrasodium

PSB-1114 tetrasodium 

Cat. No.: HY-110092
Handling Instructions

PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors.

For research use only. We do not sell to patients.

PSB-1114 tetrasodium Chemical Structure

PSB-1114 tetrasodium Chemical Structure

CAS No. : 1657025-60-9

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Description

PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors[1].

IC50 & Target

EC50: 134 nM (P2Y2 receptor), 9.3 μM (P2Y4 receptor); 7.0 μM (P2Y6 receptor)[1]

In Vitro

PSB-1114 (4-Thio-β,γ-difluoromethylene-UTP; compound 14g) displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Because of its high potency, selectivity, and expected metabolic stability toward ectonucleotidases, in particular NTPDases, PSB-1114 may be a useful pharmacological tool for studying P2Y2 receptors[1].

Molecular Weight

622.14

Formula

C₁₀H₁₁F₂N₂Na₄O₁₃P₃S

CAS No.

1657025-60-9

SMILES

O[[email protected]]1[[email protected]](N2C(NC(C=C2)=S)=O)O[[email protected]](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[[email protected]]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PSB-1114 tetrasodiumP2Y ReceptorP2Y2commercialsourcesectonucleotidasestablemetabolicInhibitorinhibitorinhibit

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PSB-1114 tetrasodium
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HY-110092
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