PSB-1114 tetrasodium 

PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors^[1].

EC50: 134 nM (P2Y₂ receptor), 9.3 μM (P2Y₄ receptor); 7.0 μM (P2Y₆ receptor)^[1]

PSB-1114 (4-Thio-β,γ-difluoromethylene-UTP; compound 14g) displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Because of its high potency, selectivity, and expected metabolic stability toward ectonucleotidases, in particular NTPDases, PSB-1114 may be a useful pharmacological tool for studying P2Y2 receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

622.14

C₁₀H₁₁F₂N₂Na₄O₁₃P₃S

1657025-60-9

O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90.  [Content Brief]

  [2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.  [Content Brief]