PSB-1114 tetrasodium
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors.
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- CAS No.: 1657025-60-9
- Formule: C10H11F2N2Na4O13P3S
- Masse moléculaire:622.14
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
EC50: 134 nM (P2Y2 receptor), 9.3 μM (P2Y4 receptor); 7.0 μM (P2Y6 receptor)[1]
PSB-1114 (4-Thio-β,γ-difluoromethylene-UTP; compound 14g) displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Because of its high potency, selectivity, and expected metabolic stability toward ectonucleotidases, in particular NTPDases, PSB-1114 may be a useful pharmacological tool for studying P2Y2 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1657025-60-9
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Masse moléculaire 622.14
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Formule C10H11F2N2Na4O13P3S
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SMILES
O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. [Content Brief]
[2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSB-1114 tetrasodium Related Classifications
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