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  3. GW 9578

GW 9578 

Cat. No.: HY-117196
Handling Instructions

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity.

For research use only. We do not sell to patients.

GW 9578 Chemical Structure

GW 9578 Chemical Structure

CAS No. : 247923-29-1

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Description

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].

IC50 & Target

mouse PPARα

5 nM (EC50)

h-PPARα

50 nM (EC50)

In Vitro

GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μm, respectively[2].
Treatment of the CD8+ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity[3].
Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

492.62

Formula

C26H34F2N2O3S

CAS No.
SMILES

CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GW 9578
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HY-117196
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