247923-29-1
247923-29-1
Chemical Structure
GW 9578
- CAS No.: 247923-29-1
- Formula:C26H34F2N2O3S
- Molecular Weight:492.62
IUPAC Name: 2-((4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenyl)thio)-2-methylpropanoic acid
InChIKey: KYQNYMXQHLMADB-UHFFFAOYSA-N
SMILES: CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O
Biological Activity: GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GW 9578 | 99.6% | GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. [Content Brief]
- [2]. Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. [Content Brief]
Keywords
