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Cat. No.: HY-158007

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(RS)-G12Di-1

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D.

For research use only. We do not sell to patients.

Formula: C₃₇H₃₅FN₆O₄
Molecular Weight:646.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

(RS)-G12Di-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D^[1].

All Ras Isoforms :

Chemical Information

Molecular Weight 646.71
Formula C₃₇H₃₅FN₆O₄
SMILES

C#CC1=CC=CC2=CC=CC(C3=C(C4=C(C(N5CC6CCC(N6C(C7CC(O7)=O)=O)C5)=NC(OCC89CCCN8CCC9)=N4)C=N3)F)=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zheng Q, et al. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat Chem Biol. Published online March 5, 2024. [Content Brief]

Calculators

Molarity Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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(RS)-G12Di-1

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(RS)-G12Di-1 Related Classifications

HY-158007 Related Classifications