Somatostatin-28 (sheep, human rat mouse)
Based on 1 Customer Validation
Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 73032-94-7
- Formula: C137H207N41O39S3
- Molecular Weight:3148.56
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SSTR5 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2]
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Dosage:1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
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Administration:Intravenous injection via a jugular catheter;
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Result:Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
Chemical Information
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CAS No. 73032-94-7
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Appearance Solid
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Molecular Weight 3148.56
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Formula C137H207N41O39S3
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Color White to off-white
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Sequence
Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge:Cys17-Cys28)
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Sequence Shortening
SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: Cys17-Cys28)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (31.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12. [Content Brief]
[2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3176 mL | 1.5880 mL | 3.1761 mL | 7.9401 mL |
| 5 mM | 0.0635 mL | 0.3176 mL | 0.6352 mL | 1.5880 mL | |
| 10 mM | 0.0318 mL | 0.1588 mL | 0.3176 mL | 0.7940 mL | |
| 15 mM | 0.0212 mL | 0.1059 mL | 0.2117 mL | 0.5293 mL | |
| 20 mM | 0.0159 mL | 0.0794 mL | 0.1588 mL | 0.3970 mL | |
| 25 mM | 0.0127 mL | 0.0635 mL | 0.1270 mL | 0.3176 mL | |
| 30 mM | 0.0106 mL | 0.0529 mL | 0.1059 mL | 0.2647 mL |
Somatostatin-28 (sheep, human rat mouse) Related Classifications
HY-P3954 Related Classifications
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