73032-94-7
Chemical Structure
Somatostatin-28 (sheep, human rat mouse)
- CAS No.: 73032-94-7
- Formula:C137H207N41O39S3
- Molecular Weight:3148.56
SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)([H])[C@H](O)C)=O)CO)=O)C(O)=O)NC(CNC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](CCSC)NC([C@H](C)NC([C@H]4N(CCC4)C([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)N[C@H]1CC7=CNC8=CC=CC=C78
Biological Activity: Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].
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Somatostatin-28 (sheep, human rat mouse) | 99.67% | Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion. | ||||||||||||||||||||
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- [1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12. [Content Brief]
- [2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7. [Content Brief]
