(1R,9S)-Dxd

Cat. No.: HY-13631K: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

(1R,9S)-Dxd is an isomer of (Dxd) HY-13631D. (1R,9S)-Dxd is an ADC payload that can be used in the synthesis of ADCs (antibody-drug conjugates).

For research use only. We do not sell to patients.

(1R,9S)-Dxd Chemical Structure

CAS No. : 2766786-58-5

Size	Price	Stock
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
25 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (1R,9S)-Dxd:

Exatecan mesylate dihydrate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(1R,9S)-Dxd is an isomer of (Dxd) HY-13631D. (1R,9S)-Dxd is an ADC payload that can be used in the synthesis of ADCs (antibody-drug conjugates)^[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

493.48

Formula

C₂₆H₂₄FN₃O₆

CAS No.

2766786-58-5

Appearance

Solid

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (202.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0264 mL	10.1321 mL	20.2642 mL
5 mM	0.4053 mL	2.0264 mL	4.0528 mL
10 mM	0.2026 mL	1.0132 mL	2.0264 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (279 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0264 mL	10.1321 mL	20.2642 mL	50.6606 mL
	5 mM	0.4053 mL	2.0264 mL	4.0528 mL	10.1321 mL
	10 mM	0.2026 mL	1.0132 mL	2.0264 mL	5.0661 mL
	15 mM	0.1351 mL	0.6755 mL	1.3509 mL	3.3774 mL
	20 mM	0.1013 mL	0.5066 mL	1.0132 mL	2.5330 mL
	25 mM	0.0811 mL	0.4053 mL	0.8106 mL	2.0264 mL
	30 mM	0.0675 mL	0.3377 mL	0.6755 mL	1.6887 mL
	40 mM	0.0507 mL	0.2533 mL	0.5066 mL	1.2665 mL
	50 mM	0.0405 mL	0.2026 mL	0.4053 mL	1.0132 mL
	60 mM	0.0338 mL	0.1689 mL	0.3377 mL	0.8443 mL
	80 mM	0.0253 mL	0.1267 mL	0.2533 mL	0.6333 mL
	100 mM	0.0203 mL	0.1013 mL	0.2026 mL	0.5066 mL

(1R,9S)-Dxd Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,9S)-Dxd2766786-58-5ADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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