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Cat. No.: HY-139449

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CDK4/6-IN-5

CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with K_is of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (from patent WO2019207463A1 example A93).

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CAS No.: 2380321-50-4
Formule: C₂₂H₂₈ClFN₆O₄S
Masse moléculaire:527.01

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CDK4/6-IN-5 Chemical Structure

CAS No.: 2380321-50-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with K_is of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively^[1]. (from patent WO2019207463A1 example A93).

Voir tous les produits spécifiques à Isoform CDK :

In Vitro

The CDK4 and CDK6 cell-based IC₅₀s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2380321-50-4
Masse moléculaire 527.01
Formule C₂₂H₂₈ClFN₆O₄S
SMILES

CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](CN(CC4)S(C)(=O)=O)O)=NC=C3Cl)=CC(F)=C2N=C1[C@H](O)C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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CDK4/6-IN-5

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CDK4/6-IN-5 Related Classifications

HY-139449 Related Classifications