LY3154885
LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile.
For research use only. We do not sell to patients.
- CAS No.: 2379422-72-5
- Formula: C23H23Cl2N3O2
- Molecular Weight:444.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
16.4 nM
Compound: 1
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Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay
Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay
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[PMID: 31938453] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2379422-72-5
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Molecular Weight 444.35
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Formula C23H23Cl2N3O2
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SMILES
CN1N=CC(C2=CC=CC3=C2C[C@H](CO)N(C(CC4=C(Cl)C=CC=C4Cl)=O)[C@H]3C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3154885 Related Classifications
HY-144291 Related Classifications
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