Anti-LAG-3 Antibody (BAP050) 

Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with K_d values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977)^[1].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Human

Anti-LAG-3 Antibody (BAP050) (2-fold serial concentration dilution; 300 sec association, 300 sec dissociation) binds to purified hLAG3 with an equilibrium dissociation constant K_D of 9.0 nM^[1].
Anti-LAG-3 Antibody (BAP050) (10 μg/mL; 30 min) targets the D1 domain of hLAG3, and its epitope is mainly composed of D1 determinants outside the 30-amino-acid-residue D1 loop^[1].
Anti-LAG-3 Antibody (BAP050) and 22D2 recognize non-overlapping epitopes on hLAG3, as they form a stable ternary complex with hLAG3 in Expi293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3902  [NCBI]

P18627

LAG3/CD223

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Agnihotri P, et al. Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3. J Immunol. 2022 Oct 15;209(8):1586-1594.