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Cat. No.: HY-P10239

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Tyr3-Octreotate

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Tyr3-Octreotate is a ligand for somatostatin receptor subtype 2 (sst2), with an IC₅₀ value of 1.3 nM against sst2 when labeled with [¹¹¹In-DTPA], and an IC₅₀ value of 1.6 nM against sst2 when labeled with [⁹⁰Y-DOTA]. Radiolabeled Tyr3-Octreotate generates cell-associated radioactivity, and acts as both a tumor growth inhibitor and a tumor cytotoxic agent. When radiolabeled with ¹⁷⁷Lu or ⁹⁰Y, Tyr3-Octreotate serves as a peptide receptor radionuclide therapy (PRRT) analog. Tyr3-Octreotate can be used in studies related to pancreatic tumors.

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Pureté: 99.76%
CAS No.: 302794-43-0
Formule: C₄₉H₆₄N₁₀O₁₂S₂
Masse moléculaire:1049.22

Stockage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Tyr3-Octreotate Chemical Structure

CAS No.: 302794-43-0

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

SSTR2

RDC Peptide

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In Vitro

Unlabeled Tyr³-octreotate (3×10^-8-3×10^-7 M; 1 hour) minimally reduces colony formation in CA20948 rat pancreatic tumor cells, with only a 5-10% reduction in cell survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

¹⁷⁷Lu-labeled Tyr3-Octreotate (277.5-555 MBq; single administration, two dose levels) cures rats bearing small CA20948 tumors, and achieves a maximum cure rate of 50% in rats bearing larger tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

specific strain not specified^[1]
Dosage:

277.5 MBq (small tumors, 2 doses; large tumors, single dose; large tumors, 2 doses); 555 MBq (small tumors, single dose)
Administration:

i.v.; single dose; 2 doses
Result:

Achieved a 40% cure rate in rats with larger tumors treated with a single dose of 277.5 MBq.
Achieved a 50% cure rate in rats with larger tumors treated with two doses of 277.5 MBq.

Chemical Information

CAS No. 302794-43-0
Appearance Solid
Masse moléculaire 1049.22
Formule C₄₉H₆₄N₁₀O₁₂S₂
Color White to off-white
Sequence

{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge: Cys2-Cys7)
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Capello A, et al. Tyr3-octreotide and Tyr3-octreotate radiolabeled with 177Lu or 90Y: peptide receptor radionuclide therapy results in vitro. Cancer Biother Radiopharm. 2003 Oct;18(5):761-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Tyr3-Octreotate

Voir tous les produits spécifiques à Isoform Somatostatin Receptor

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