Tyr3-Octreotate
Based on 1 Customer Validation
Tyr3-Octreotate is a ligand for somatostatin receptor subtype 2 (sst2), with an IC50 value of 1.3 nM against sst2 when labeled with [111In-DTPA], and an IC50 value of 1.6 nM against sst2 when labeled with [90Y-DOTA]. Radiolabeled Tyr3-Octreotate generates cell-associated radioactivity, and acts as both a tumor growth inhibitor and a tumor cytotoxic agent. When radiolabeled with 177Lu or 90Y, Tyr3-Octreotate serves as a peptide receptor radionuclide therapy (PRRT) analog. Tyr3-Octreotate can be used in studies related to pancreatic tumors.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 302794-43-0
- Formula: C49H64N10O12S2
- Molecular Weight:1049.22
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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SSTR2 |
RDC Peptide |
Unlabeled Tyr3-octreotate (3×10-8-3×10-7 M; 1 hour) minimally reduces colony formation in CA20948 rat pancreatic tumor cells, with only a 5-10% reduction in cell survival[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:specific strain not specified[1]
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Dosage:277.5 MBq (small tumors, 2 doses; large tumors, single dose; large tumors, 2 doses); 555 MBq (small tumors, single dose)
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Administration:i.v.; single dose; 2 doses
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Result:Achieved a 40% cure rate in rats with larger tumors treated with a single dose of 277.5 MBq.
Achieved a 50% cure rate in rats with larger tumors treated with two doses of 277.5 MBq.
Chemical Information
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CAS No. 302794-43-0
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Appearance Solid
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Molecular Weight 1049.22
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Formula C49H64N10O12S2
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Color White to off-white
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Sequence
{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge: Cys2-Cys7)
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Sequence Shortening
{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge: Cys2-Cys7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyr3-Octreotate Related Classifications
HY-P10239 Related Classifications
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