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1427

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13

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12

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25

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99

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1

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24

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117

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79

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114

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4

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2221C
    CM Cellulose CM-32

    Carboxymethyl cellulose CM-32; CM-32

    		 Environmental Pollutants Biochemical Assay Reagents Others
    CM Cellulose CM-32 (Carboxymethyl cellulose) is a cellulose derivative. CM Cellulose CM-32 has a wide range of applications in the biomedical field, including tissue engineering, wound dressing, absorbent nonwovens, fabrication of 3D-scaffolds for biocompatible implants, artificial organs or mimics of extracellular polymeric matrix and diagnosis of various diseases. CM Cellulose CM-32 can decrease osteoclasts formation. CM Cellulose CM-32 can be used as a biological material or organic compound for life science related research .
    CM Cellulose CM-32
  • HY-130835
    FKBP12 PROTAC RC32

    RC32

    		 PROTACs FKBP Cancer
    FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984) .
    FKBP12 PROTAC RC32
  • HY-148847
    HPK1-IN-32

    		MAP4K Cancer
    HPK1-IN-32 is a potent and selective HPK1 inhibitor with an IC50 of 65 nM. HPK1-IN-32 can be used for the research of HPK1 related disorders or diseases .
    HPK1-IN-32
  • HY-176862
    TCB-32

    		FGFR ERK Inflammation/Immunology
    TCB-32 (Compound I-1) is a FGFR1 agonist with an EC50 of 0.88  μM. TCB-32 significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 can replace bFGF in serum-free cell culture media. TCB-32 can be used for tissue repair and wound healing related diseases like psoriasis and eczema research .
    TCB-32
  • HY-178124
    Huib32

    		Deubiquitinase Neurological Disease Cancer
    Huib32 is a potent small-molecule inhibitor of USP32 (IC50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research .
    Huib32
  • HY-P2196A
    ELA-32(human) TFA
    1 Publications Verification

    		 Apelin Receptor (APJ) Cancer
    ELA-32(human) TFA is a potent, high affinity apelin receptor agonist (IC50=0.27 nM; Kd=0.51 nM). ELA-32(human) TFA exhibits no binding GPR15 and GPR25. ELA-32(human) TFA activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. ELA-32(human) TFA also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. ELA-32(human) TFA stimulates angiogenesis in HUVEC cells.
    ELA-32(human) TFA
  • HY-134903
    (32-Carbonyl)-RMC-5552

    		mTOR Cancer
    (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) .
    (32-Carbonyl)-RMC-5552
  • HY-117997
    UMB-32

    		Epigenetic Reader Domain Cancer
    UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor .
    UMB-32
  • HY-P1519B
    Brain Natriuretic Peptide (1-32), rat acetate

    BNP (1-32), rat acetate

    		 Angiotensin Receptor Cardiovascular Disease
    Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
    Brain Natriuretic Peptide (1-32), rat acetate
  • HY-I0393
    3-(2-Thienyl)-L-alanine

    L-3-(2-Thienyl)alanine

    		 Amino Acid Derivatives Others
    3-(2-Thienyl)-L-alanine is an alanine derivative .
    3-(2-Thienyl)-L-alanine
  • HY-78866
    3-(2-ChloropyriMidin-4-yl)-1-methylindole

    		Drug Intermediate Others
    3-(2-ChloropyriMidin-4-yl)-1-methylindole is a drug intermediate for synthesis of various active compounds.
    3-(2-ChloropyriMidin-4-yl)-1-methylindole
  • HY-D0096
    3-(2-Furoyl)quinoline-2-carboxaldehyde

    		Fluorescent Dye Others
    3-(2-Furoyl)quinoline-2-carboxaldehyde is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
    3-(2-Furoyl)quinoline-2-carboxaldehyde
  • HY-148783
    HBV-IN-32

    		HBV Infection
    HBV-IN-32 is a potent cccDNA (covalently closed circular DNA) inhibitor. HBV-IN-32 shows anti-HBV activity with an IC50 value of 0.14 µM for HBsAg. HBV-IN-32 inhibits cell growth .
    HBV-IN-32
  • HY-171745
    ATR-IN-32

    		ATM/ATR Cancer
    ATR-IN-32 is an orally active ATR inhibitor. ATR-IN-32 potently inhibits the proliferation of MIA PaCa-2 cells. ATR-IN-32 exerts significant tumor growth inhibition in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 can be used for the study of cancers mediated by ATR protein kinase, such as colorectal cancer, pancreatic cancer .
    ATR-IN-32
  • HY-132221
    CU-32

    		Cyclic GMP-AMP Synthase Inflammation/Immunology
    CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells .
    CU-32
  • HY-P1519
    Brain Natriuretic Peptide (1-32), rat

    BNP (1-32), rat

    		 Angiotensin Receptor Cardiovascular Disease
    Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes) .
    Brain Natriuretic Peptide (1-32), rat
  • HY-150156
    Anti-inflammatory agent 32

    		Drug Derivative Inflammation/Immunology
    Anti-inflammatory agent 32 (compound C3) has anti-oxidative and anti-inflammatory activity. Anti-inflammatory agent 32 can be used for skin care products research and development .
    Anti-inflammatory agent 32
  • HY-108248
    KU-32

    		HSP Cardiovascular Disease Neurological Disease Metabolic Disease
    KU-32 is a novel, novobiocin-based Hsp90 inhibitor that can protect against neuronal cell death.
    KU-32
  • HY-W141842
    3-(2-Thienyl)-DL-alanine

    		Amino Acid Derivatives Others
    3-(2-Thienyl)-DL-alanine is an alanine derivative .
    3-(2-Thienyl)-DL-alanine
  • HY-130157
    3-(2-Pyridyldithio)propanoic Acid

    		PROTAC Linkers Cancer
    3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
    3-(2-Pyridyldithio)propanoic Acid
  • HY-76089
    tert-Butyl 3-(1-amino-2-methylpropan-2-yl)-1H-indole-1-carboxylate

    3-(2-Amino-1,1-dimethylethyl)-indole-1-carboxylic acid tert-butyl ester

    		 Drug Intermediate Others
    tert-Butyl 3-(1-amino-2-methylpropan-2-yl)-1H-indole-1-carboxylate (3-(2-Amino-1,1-dimethylethyl)-indole-1-carboxylic acid tert-butyl ester) is a drug intermediate for synthesis of various active compounds.
    tert-Butyl 3-(1-amino-2-methylpropan-2-yl)-1H-indole-1-carboxylate
  • HY-P10259
    BNP(1-32), porcine

    pBNP-32

    		 Natriuretic Peptide Receptor (NPR) Neurological Disease
    BNP(1-32), porcine (pBNP-32) is a cardiac hormone. BNP(1-32), porcine is an atrial natriuretic peptide, which exhibits natriuretic, diuretic and vasorelaxant effects. BNP(1-32), porcine affects passive avoidance learning in rats with dopaminergic, cholinergic, α-and β-adrenergic mediation .
    BNP(1-32), porcine
  • HY-176862A
    TCB-32 hydrochloride

    		FGFR ERK Inflammation/Immunology
    TCB-32 (Compound I-1) hydrochloride is a FGFR1 agonist with an EC50 of 0.88  μM. TCB-32 hydrochloride significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 hydrochloride can replace bFGF in serum-free cell culture media. TCB-32 hydrochloride can be used for tissue repair and wound healing related diseases like psoriasis and eczema research .
    TCB-32 hydrochloride
  • HY-178941
    DHODH-IN-32

    		Dihydroorotate Dehydrogenase Apoptosis Caspase Reactive Oxygen Species (ROS) Cancer
    DHODH-IN-32 (Compound A1) is a DHODH inhibitor. DHODH-IN-32 shows significant cytotoxicity against NCI-60 cell lines, especially being sensitive to breast cancer, prostate cancer and leukemia cell lines. DHODH-IN-32 can induce cell apoptosis by activating the Caspase pathway. DHODH-IN-32 causes G0/G1 phase cell cycle arrest and inhibits cellular metabolism by ROS. DHODH-IN-32 exhibits significant anti-tumor properties in mouse breast cancer models. DHODH-IN-32 can be used for the study of breast cancer .
    DHODH-IN-32
  • HY-174437
    FLT3-IN-32

    		FLT3 Apoptosis Cancer
    FLT3-IN-32 is a potent and orally active FLT3 inhibitor. FLT3-IN-32 shows high selectivity for FLT3 and efficiently inhibits FLT3-activating mutations and induces apoptosis. FLT3-IN-32 shows good tolerability in non-tumor bearing mice. FLT3-IN-32 demonstrates outstanding anti-tumor efficacy in MV4-11 bearing NOD/SCID mice, prolonging the survival noticeably. FLT3-IN-32 can be used for the research of acute myeloid leukemia .
    FLT3-IN-32
  • HY-178954
    IDO1-IN-32

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO1-IN-32 (Compound 45) is a potent and orally effective IDO1 inhibitor with an IC50 of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer .
    IDO1-IN-32
  • HY-P5757
    (D-Trp32)-Neuropeptide Y (porcine)

    (D-Trp32)-NPY

    		 Neuropeptide Y Receptor Neurological Disease
    (D-Trp32)-Neuropeptide Y (porcine) is a highly selective neuropeptide Y (NPY) Y5 receptor agonist. (D-Trp32)-Neuropeptide Y (porcine) has orexigenic activity and inhibits Forskolin (HY-15371)-stimulated cAMP formation .
    (D-Trp32)-Neuropeptide Y (porcine)
  • HY-W011857R
    3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid (Standard)

    		Reference Standards
    3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid (Standard) is the analytical standard of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid. This product is intended for research and analytical applications.
    3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid (Standard)
  • HY-W048002
    3-(2-Chloroacetyl)-1H-indole-5-carbonitrile

    		Drug Intermediate Others
    3-(2-Chloroacetyl)-1H-indole-5-carbonitrile is a drug intermediate for synthesis of various active compounds.
    3-(2-Chloroacetyl)-1H-indole-5-carbonitrile
  • HY-W089929
    2-(3-(Pyridin-4-yl)-1H-1,2,4-triazol-5-yl)pyridine

    3-(2-Pyridyl)-5-(4-Pyridyl)-1,2,4-Triazole

    		 MOFs Others
    2-(3-(Pyridin-4-yl)-1H-1,2,4-triazol-5-yl)pyridine (3-(2-Pyridyl)-5-(4-Pyridyl)-1,2,4-Triazole) is a metal-organic framework (MOF).
    2-(3-(Pyridin-4-yl)-1H-1,2,4-triazol-5-yl)pyridine
  • HY-W747554
    SM 32

    		nAChR Neurological Disease
    SM 32 is an analgesic. SM 32 produces an increase in ACh release. SM 32 amplifies electrically- and nicotine- evoked guinea-pig ileum contractions. SM32 induces antinociceptive effects through a central cholinergic mechanism .
    SM 32
  • HY-122221
    KUM 32

    		Adrenergic Receptor Adenylate Cyclase Cardiovascular Disease
    KUM 32 is a potent antagonist of epinephrine-induced platelet aggregation. KUM 32 is an adenylate cyclase activity inhibitor. KUM 32 binds to the alpha 2 adrenergic receptor of human platelets .
    KUM 32
  • HY-P991527
    Anti-CD32b Antibody (HuMax-CD32b)

    		Transmembrane Glycoprotein Others
    Anti-CD32b Antibody (HuMax-CD32b) is a humanized antibody against CD32b.
    Anti-CD32b Antibody (HuMax-CD32b)
  • HY-146116
    Antifungal agent 32

    		Fungal Infection
    Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .
    Antifungal agent 32
  • HY-149252
    Tubulin inhibitor 32

    		Apoptosis Microtubule/Tubulin Cancer
    Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity .
    Tubulin inhibitor 32
  • HY-143303
    Anticancer agent 32

    		Apoptosis Cancer
    Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer .
    Anticancer agent 32
  • HY-176512
    FO-32

    		Liposome Cancer
    FO-32 is an ionizable cationic lipid with a pKa of 6.46 and can be used to generate lipid nanoparticles (LNPs) to deliver mRNA in vivo. FO-32 can efficiently deliver mRNA to ferret lungs. FO-32 can be studied in research on optimizing drug delivery .
    FO-32
  • HY-161453
    BChE-IN-32

    		Cholinesterase (ChE) Neurological Disease
    ChE-IN-32 (compound 5d) is a potent and selective hBChE inhibitor with an IC50 value of 0.109 µM. BChE-IN-32 shows cytotoxicity. BChE-IN-32 has the potential for the research of Alzheimer's disease .
    BChE-IN-32
  • HY-164632
    KRAS inhibitor-32

    		Ras Cancer
    KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor. KRAS inhibitor-32 can be used in anti-cancer research .
    KRAS inhibitor-32
  • HY-168872
    API32

    		PIN1 Cancer
    API32 is a potent Pin1 inhibitor. API32 interactes with the Pin1 PPIase domain. API32 inhibits cell proliferation and migration. API32 has the potential for the research of hepatocellular carcinoma (HCC) .
    API32
  • HY-151393
    Tubulin polymerization-IN-32

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-32 is a tubulin polymerization inhibitor. Tubulin polymerization-IN-32 inhibits cancer cell proliferation. Tubulin polymerization-IN-32 can be used in the research of cancers like lymphomas .
    Tubulin polymerization-IN-32
  • HY-113641
    ROCK-IN-32

    		ROCK Cardiovascular Disease Inflammation/Immunology Cancer
    ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2. ROCK-IN-32 can be used in research of cardiovascular disease, cancer and inflammation .
    ROCK-IN-32
  • HY-124687
    ROMK-IN-32

    		Potassium Channel Cardiovascular Disease
    ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM .
    ROMK-IN-32
  • HY-P5671
    Maximin 32

    		Bacterial Infection
    Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .
    Maximin 32
  • HY-145687
    HDAC-IN-32

    		HDAC Cancer
    HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity .
    HDAC-IN-32
  • HY-159586
    Tyrosinase-IN-32

    		Tyrosinase Cancer
    Tyrosinase-IN-32 (compound 11) is a hydroxamate-based alkaloid and a mushroom tyrosinase inhibitor. Tyrosinase-IN-32 has antioxidant activity and can be isolated from black pepper (Piper nigrum L.) .
    Tyrosinase-IN-32
  • HY-162081
    BTK-IN-32

    		Btk Cancer
    BTK-IN-32 (compound C2) is a potent inhibitor of BTK. BTK-IN-32 activates full-length BTK and smaller multidomain BTK fragments instead of the isolated kinase domain .
    BTK-IN-32
  • HY-168179
    RORγt inverse agonist 32

    		ROR Inflammation/Immunology
    RORγt inverse agonist 32 (compound b14) is orally active. RORγt inverse agonist 32 can be used in inflammation research .
    RORγt inverse agonist 32
  • HY-175302
    TRK-IN-32

    		Trk Receptor Apoptosis Cancer
    TRK-IN-32 is a potent TRK inhibitor. TRK-IN-32 potently inhibits TRK WT, TRK G595R and TRK G667C with IC50 values of 0.08 nM, 2.14 nM and 0.68 nM, respectively. TRK-IN-32 also demonstrates antiproliferative activity against a panel of Ba/F3 cell lines transformed with wild type, xDFG, solvent-front as well as gatekeeper mutant TRK fusion proteins. TRK-IN-32 induces apoptosis of Ba/F3-TRKA WT and Ba/F3-TRKA G667C cells.TRK-IN-32 can be used for the study of various cancers (such as thyroid cancer, secretory breast carcinoma) .
    TRK-IN-32
  • HY-155124
    Antiproliferative agent-32

    		Apoptosis Cancer
    Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma .
    Antiproliferative agent-32

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