YE120
YE120 is a potent GPR35 agonist with an EC50 of 32.5 nM.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 383124-82-1
- Formula: C16H9Cl2N3O
- Molecular Weight:330.17
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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RNA Binding Bioactive Compound Library
HY-L248
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Lactylation Compound Library
HY-L249
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | EC50 |
0.032 μM
Compound: 1, YE120
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Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay
Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay
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[PMID: 21950657] |
| HT-29 | IC50 |
0.06 μM
Compound: 1, YE120
|
Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay
Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay
|
[PMID: 21950657] |
| U2OS | EC50 |
10.2 μM
Compound: 1, YE120
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Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay
Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay
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[PMID: 21950657] |
Chemical Information
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CAS No. 383124-82-1
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Appearance Solid
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Molecular Weight 330.17
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Formula C16H9Cl2N3O
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Color White to off-white
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SMILES
N#C/C(C#N)=C1OC(C(C)=C/1C#N)(C)C2=CC=C(C(Cl)=C2)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33 mg/mL (99.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0287 mL | 15.1437 mL | 30.2874 mL | 75.7186 mL |
| 5 mM | 0.6057 mL | 3.0287 mL | 6.0575 mL | 15.1437 mL | |
| 10 mM | 0.3029 mL | 1.5144 mL | 3.0287 mL | 7.5719 mL | |
| 15 mM | 0.2019 mL | 1.0096 mL | 2.0192 mL | 5.0479 mL | |
| 20 mM | 0.1514 mL | 0.7572 mL | 1.5144 mL | 3.7859 mL | |
| 25 mM | 0.1211 mL | 0.6057 mL | 1.2115 mL | 3.0287 mL | |
| 30 mM | 0.1010 mL | 0.5048 mL | 1.0096 mL | 2.5240 mL | |
| 40 mM | 0.0757 mL | 0.3786 mL | 0.7572 mL | 1.8930 mL | |
| 50 mM | 0.0606 mL | 0.3029 mL | 0.6057 mL | 1.5144 mL | |
| 60 mM | 0.0505 mL | 0.2524 mL | 0.5048 mL | 1.2620 mL | |
| 80 mM | 0.0379 mL | 0.1893 mL | 0.3786 mL | 0.9465 mL |
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