CypD-IN-6
CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM). CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.
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- Fòrmula: C19H22BrN5O2
- Peso molecular:432.31
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Ver todos los productos específicos de isoformas Cyclophilin
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Actividad biológica
Descripciòn
IC50 & Target
1|
Cyclophilin D 32 nM (Ki) |
In Vitro
CypD-IN-6 (12a) (10 μM) increases mitochondrial calcium retention capacity (CRC) in isolated mouse liver mitochondria[1].
CypD-IN-6 shows no protection in mitochondria isolated from CypD knockout (Ppif-/-) mice, which is consistent with a CypD-dependent mechanism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 432.31
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Fòrmula C19H22BrN5O2
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SMILES
NC1=CC=C(C=C1)CNC(NCC(N2N(CCC2)C3=CC=CC=C3Br)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CypD-IN-6 Related Classifications
HY-179416 Related Classifications
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