CypD-IN-6
CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM). CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.
For research use only. We do not sell to patients.
- Formula: C19H22BrN5O2
- Molecular Weight:432.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cyclophilin Isoforms
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Biological Activity
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Cyclophilin D 32 nM (Ki) |
CypD-IN-6 (12a) (10 μM) increases mitochondrial calcium retention capacity (CRC) in isolated mouse liver mitochondria[1].
CypD-IN-6 shows no protection in mitochondria isolated from CypD knockout (Ppif-/-) mice, which is consistent with a CypD-dependent mechanism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 432.31
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Formula C19H22BrN5O2
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SMILES
NC1=CC=C(C=C1)CNC(NCC(N2N(CCC2)C3=CC=CC=C3Br)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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