TMA-IN-1
TMA-IN-1 (Compound 7) is a highly potent, orally active and selective TMA Lyase inhibitor with an estimated Kd value of 3.2 μM. TMA-IN-1 reduces Trimethylamine oxide (TMAO) levels. TMA-IN-1 can be used for the research of heart failure.
For research use only. We do not sell to patients.
- CAS No.: 160172-20-3
- Formula: C9H13NO
- Molecular Weight:151.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
TMA-IN-1 (100 μM) binds to recombinant TMA lyase, with an estimated Kd value of 3.2 μM[1].
TMA-IN-1 (5 μM) shows low binding rate to rodent plasma proteins (the unbound fraction is 85% in mice and 90% in rats)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TMA-IN-1 (10-80 mg/kg; p.o.; single dose) significantly reduces circulating TMAO levels in fecal microbiota-transplanted mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 160172-20-3
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Molecular Weight 151.21
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Formula C9H13NO
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SMILES
O[C@]1(C#C)CN2CCC1CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TMA-IN-1 Related Classifications
HY-W589560 Related Classifications
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