TMA-IN-1 

TMA-IN-1 (Compound 7) is a highly potent, orally active and selective TMA Lyase inhibitor with an estimated K_d value of 3.2 μM. TMA-IN-1 reduces Trimethylamine oxide (TMAO) levels. TMA-IN-1 can be used for the research of heart failure^[1].

TMA-IN-1 (100 μM) binds to recombinant TMA lyase, with an estimated K_d value of 3.2 μM^[1].
TMA-IN-1 (5 μM) shows low binding rate to rodent plasma proteins (the unbound fraction is 85% in mice and 90% in rats)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TMA-IN-1 (5-250 mg/kg; p.o.) significantly reduces circulating TMAO levels in rats^[1].
TMA-IN-1 (10-80 mg/kg; p.o.; single dose) significantly reduces circulating TMAO levels in fecal microbiota-transplanted mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

151.21

C₉H₁₃NO

160172-20-3

O[C@]1(C#C)CN2CCC1CC2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pettersson M, et al. Discovery of a Highly Potent and Selective Small-Molecule Inhibitor of In Vivo Anaerobic Choline Metabolism by Human Gut Bacteria. J Med Chem. 2026;69(3):2115-2129.  [Content Brief]