Antiproliferative agent-13

Name: Antiproliferative agent-13
Brand: MedChemExpress
SKU: HY-128224
Rating: 4.5 (1 reviews)

Cat. No.: HY-128224 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC₅₀ value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer.

For research use only. We do not sell to patients.

Antiproliferative agent-13 Chemical Structure

CAS No. : 663214-48-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 32.7 nM (A375 cells)^[1]

In Vitro

Antiproliferative agent-13 (0-10 μM; 72 h) affects proliferation of human A375 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	A375 melanoma cell line
Concentration:	0-10000 nM
Incubation Time:	72 hours
Result:	Showed an anti-proliferative activity to human A375 melanoma cells with an IC₅₀ value of 32.7 nM.

Molecular Weight

382.37

Formula

C₂₀H₁₈N₂O₆

CAS No.

663214-48-0

Appearance

Solid

Color

White to light yellow

SMILES

N#CC1=C(N)OC2=CC(OCO3)=C3C=C2C1C4=CC(OC)=C(OC)C(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (130.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6153 mL	13.0763 mL	26.1527 mL
5 mM	0.5231 mL	2.6153 mL	5.2305 mL
10 mM	0.2615 mL	1.3076 mL	2.6153 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (261 KB) HNMR (255 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang H, et al. Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities. Eur J Med Chem. 2018 Sep 5;157:380-396 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6153 mL	13.0763 mL	26.1527 mL	65.3817 mL
	5 mM	0.5231 mL	2.6153 mL	5.2305 mL	13.0763 mL
	10 mM	0.2615 mL	1.3076 mL	2.6153 mL	6.5382 mL
	15 mM	0.1744 mL	0.8718 mL	1.7435 mL	4.3588 mL
	20 mM	0.1308 mL	0.6538 mL	1.3076 mL	3.2691 mL
	25 mM	0.1046 mL	0.5231 mL	1.0461 mL	2.6153 mL
	30 mM	0.0872 mL	0.4359 mL	0.8718 mL	2.1794 mL
	40 mM	0.0654 mL	0.3269 mL	0.6538 mL	1.6345 mL
	50 mM	0.0523 mL	0.2615 mL	0.5231 mL	1.3076 mL
	60 mM	0.0436 mL	0.2179 mL	0.4359 mL	1.0897 mL
	80 mM	0.0327 mL	0.1635 mL	0.3269 mL	0.8173 mL
	100 mM	0.0262 mL	0.1308 mL	0.2615 mL	0.6538 mL