Antiproliferative agent-13
Based on 1 Customer Validation
Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC50 value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.09%
- CAS No.: 663214-48-0
- Formula: C20H18N2O6
- Molecular Weight:382.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 32.7 nM (A375 cells)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
32.7 nM
Compound: 16c
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Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
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[PMID: 30099258] |
Antiproliferative agent-13 (0-10 μM; 72 h) affects proliferation of human A375 melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375 melanoma cell line
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Concentration:0-10000 nM
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Incubation Time:72 hours
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Result:Showed an anti-proliferative activity to human A375 melanoma cells with an IC50 value of 32.7 nM.
Chemical Information
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CAS No. 663214-48-0
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Appearance Solid
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Molecular Weight 382.37
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Formula C20H18N2O6
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Color White to light yellow
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SMILES
N#CC1=C(N)OC2=CC(OCO3)=C3C=C2C1C4=CC(OC)=C(OC)C(OC)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (130.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6153 mL | 13.0763 mL | 26.1527 mL | 65.3817 mL |
| 5 mM | 0.5231 mL | 2.6153 mL | 5.2305 mL | 13.0763 mL | |
| 10 mM | 0.2615 mL | 1.3076 mL | 2.6153 mL | 6.5382 mL | |
| 15 mM | 0.1744 mL | 0.8718 mL | 1.7435 mL | 4.3588 mL | |
| 20 mM | 0.1308 mL | 0.6538 mL | 1.3076 mL | 3.2691 mL | |
| 25 mM | 0.1046 mL | 0.5231 mL | 1.0461 mL | 2.6153 mL | |
| 30 mM | 0.0872 mL | 0.4359 mL | 0.8718 mL | 2.1794 mL | |
| 40 mM | 0.0654 mL | 0.3269 mL | 0.6538 mL | 1.6345 mL | |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5231 mL | 1.3076 mL | |
| 60 mM | 0.0436 mL | 0.2179 mL | 0.4359 mL | 1.0897 mL | |
| 80 mM | 0.0327 mL | 0.1635 mL | 0.3269 mL | 0.8173 mL | |
| 100 mM | 0.0262 mL | 0.1308 mL | 0.2615 mL | 0.6538 mL |
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