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ARV-771 (Standard)

ARV-771 (Standard) is the analytical standard of ARV-771 (HY-100972). This product is intended for research and analytical applications. ARV-771 is a BET PROTAC degrader, with Kd values of 34, 4.7, 8.3, 7.6, 9.6 and 7.6 nM against BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) , respectively. ARV-771 inhibits the transcription of AR/AR-v7 and its downstream target genes. By degrading BRD4 protein, ARV-771 enhances the sensitivity of prostate cancer cells to ferroptosis, suppresses cancer cell viability, and induces apoptosis. ARV-771 downregulates the levels of BRD4, c-MYC and AR-V7 in tumor tissues and inhibits tumor tissue growth. ARV-771 can be used in prostate cancer-related research.
(Pink: BET ligand (HY-78695); Blue: VHL ligand (HY-112078); Black: linker).

For research use only. We do not sell to patients.

  • CAS No.: 1949837-12-0
  • Formula: C49H60ClN9O7S2
  • Molecular Weight:986.64
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • ARV-771 (Standard) Chemical Structure
    ARV-771 (Standard) Chemical Structure
CAS No.: 1949837-12-0
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  • ARV-771 (Standard) Chemical Structure
    ARV-771 (Standard) Chemical Structure
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  • ARV-771 (Standard)