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Human Serum Albumin Antibody (YA985)

(Synonyms: ALB; ALBU_HUMAN; Albumin (32 AA); Albumin (AA 34); Albumin; Analbuminemia; Bisalbuminemia; Cell growth inhibiting protein 42; DKFZp779N1935; Dysalbuminemic hyperthyroxinemia; Growth inhibiting protein 20; HSA; Hyperthyroxinemia dysalbuminemic; Serum albumin.)
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Based on 1 Customer Validation

Human Serum Albumin Antibody (YA985) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Human Serum Albumin.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Human Serum Albumin Antibody (YA985)
  • Human Serum Albumin Antibody (YA985) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:1000 1:10000

Product Details

Description

Human Serum Albumin Antibody (YA985) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Human Serum Albumin.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 69 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 69 kDa
Species Reactivity Database

Entrez Gene: 213 Human

SwissProt: P02768 Human

Immunogen

Purified Human serum albumin.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3103357

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Human Serum Albumin Antibody (YA985)
    Western blot analysis was performed on extracts from Human serum-10ng (lane 1, 10ng), Human serum-5ng (lane 2, 5ng), Human serum-2ng (lane 3, 2ng), Human serum-1ng (lane 4, 1ng), Human serum-0.5ng (lane 5, 0.5ng), and Human serum-0.1ng (lane 6, 0.1ng) using Human Serum Albumin Mouse mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) was incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Mouse IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background

  • Function

    Human Serum Albumin binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin[1][2].

  • Subcellular Localization

    Secreted

  • Expression


    Tissue_specificity:plasma

  • Isoforms & Post-Translational Modification

    P02768 has 3 isomers: P02768-1: 69367 Da (predicted); P02768-2: 47360 Da (predicted); P02768-3: 45160 Da (predicted).
    Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606;Glycated in diabetic patients;Phosphorylated by FAM20C in the extracellular medium;Acetylated on Lys-223 by acetylsalicylic acid

  • Subunit

    Interacts with FCGRT; this interaction regulates ALB homeostasis (PubMed:28330995). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent fatty acid binding to ALB

  • SwissProt ID

    P02768

  • Gene ID
    213 [NCBI]
  • Synonyms

    ALB; ALBU_HUMAN; Albumin (32 AA); Albumin (AA 34); Albumin; Analbuminemia; Bisalbuminemia; Cell growth inhibiting protein 42; DKFZp779N1935; Dysalbuminemic hyperthyroxinemia; Growth inhibiting protein 20; HSA; Hyperthyroxinemia dysalbuminemic; Serum albumin.

  • Research Field

    Cardiovascular

Human Serum Albumin Antibody (YA985) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis was performed on extracts from Human serum-10ng (lane 1, 10ng), Human serum-5ng (lane 2, 5ng), Human serum-2ng (lane 3, 2ng), Human serum-1ng (lane 4, 1ng), Human serum-0.5ng (lane 5, 0.5ng), and Human serum-0.1ng (lane 6, 0.1ng) using Human Serum Albumin Mouse mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) was incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Mouse IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • Human Serum Albumin Antibody (YA985) Product Image
    1/16
  • Experimental Validation Results for Human Serum Albumin Antibody (YA985)
  • Human Serum Albumin Antibody (YA985) Product Image
  • Experimental Validation Results for Human Serum Albumin Antibody (YA985)
    1/1
    MedchemExpress Validation
     Western blot analysis was performed on extracts from Human serum-10ng (lane 1, 10ng), Human serum-5ng (lane 2, 5ng), Human serum-2ng (lane 3, 2ng), Human serum-1ng (lane 4, 1ng), Human serum-0.5ng (lane 5, 0.5ng), and Human serum-0.1ng (lane 6, 0.1ng) using Human Serum Albumin Mouse mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) was incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Mouse IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.
  • Experimental Validation Results for Human Serum Albumin Antibody (YA985)
  • Human Serum Albumin Antibody (YA985) Product Image
    MedchemExpress Validation

    Western blot analysis was performed on extracts from Human serum-10ng (lane 1, 10ng), Human serum-5ng (lane 2, 5ng), Human serum-2ng (lane 3, 2ng), Human serum-1ng (lane 4, 1ng), Human serum-0.5ng (lane 5, 0.5ng), and Human serum-0.1ng (lane 6, 0.1ng) using Human Serum Albumin Mouse mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) was incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Mouse IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • Human Serum Albumin Antibody (YA985) Product Image WB