HIV-1 inhibitor-32
HIV-1 inhibitor-32 (compound 3c) is a potent HIV-1 inhibitor with an IC50 value of 34 nM for WT HIV-1. HIV-1 inhibitor-32 can be used for researching AIDS.
For research use only. We do not sell to patients.
- CAS No.: 1033950-94-5
- Formula: C26H29N5O3S
- Molecular Weight:491.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIV-1 (WT) 34 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | IC50 |
0.3 nM
Compound: 5h
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Antiviral activity against HIV1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against HIV1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 20538456] |
| MT4 | IC50 |
16.9 nM
Compound: 5h
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Antiviral activity against HIV1 expressing reverse transcriptase Y188L mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against HIV1 expressing reverse transcriptase Y188L mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 20538456] |
| MT4 | IC50 |
20.2 nM
Compound: 5h
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Antiviral activity against HIV1 expressing reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against HIV1 expressing reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 20538456] |
Chemical Information
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CAS No. 1033950-94-5
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Molecular Weight 491.61
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Formula C26H29N5O3S
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SMILES
N#CC1=CC(C)=C(OC2=NC(NC3CCN(CC4=CC=C(S(=O)(C)=O)C=C4)CC3)=NC=C2)C(C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-32 Related Classifications
HY-146089 Related Classifications
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