p27 Analogue CP2
p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the Cks1-Skp2-Skp1 complex (Kd = 32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer.
For research use only. We do not sell to patients.
- Formula: C51H83N20O20P
- Molecular Weight:1327.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Skp2 |
p27 Analogue CP2 (Compound CP2) binds to the Cks1-Skp2-Skp1 complex with a Kd of 32 nM[1].
p27 Analogue CP2 (32.5-600 μM; 90 min) inhibits SCFSkp2/Cks1-mediated p27 poly-ubiquitination in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1327.30
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Formula C51H83N20O20P
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Sequence
Ala-Gly-Ser-{X2}-Glu-Gln-Thr{phos}-Pro-{X3}-Lys
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Sequence Shortening
AGS-{X2}-EQ-Thr{phos}-P-{X3}-K
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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