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Cat. No.: HY-P11020

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p27 Analogue CP2

p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the Cks1-Skp2-Skp1 complex (K_d = 32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer.

For research use only. We do not sell to patients.

Formula: C₅₁H₈₃N₂₀O₂₀P
Molecular Weight:1327.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

p27 Analogue CP2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Skp2

In Vitro

p27 Analogue CP2 (Compound CP2) binds to the Cks1-Skp2-Skp1 complex with a K_d of 32 nM^[1].
p27 Analogue CP2 (32.5-600 μM; 90 min) inhibits SCFSkp2/Cks1-mediated p27 poly-ubiquitination in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 1327.30
Formula C₅₁H₈₃N₂₀O₂₀P
Sequence

Ala-Gly-Ser-{X2}-Glu-Gln-Thr{phos}-Pro-{X3}-Lys
Sequence Shortening

AGS-{X2}-EQ-Thr{phos}-P-{X3}-K
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zenkevičiūtė G, et al. Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase[J]. bioRxiv, 2023: 2023.04. 27.535981.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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