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Cat. No.: HY-133030

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DNMT-IN-1

DNMT-IN-1 is a potent DNMT inhibitor with an EC₅₀ value of 3.2 µM. DNMT-IN-1 shows antiproliferative active.

For research use only. We do not sell to patients.

CAS No.: 2396691-28-2
Formula: C₁₅H₉BrN₂O₆
Molecular Weight:393.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

DNMT-IN-1 Chemical Structure

CAS No.: 2396691-28-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DNMT-IN-1 is a potent DNMT inhibitor with an EC₅₀ value of 3.2 µM. DNMT-IN-1 shows antiproliferative active^[1].

IC₅₀ & Target^[1]

DNA Methyltransferase

3.2 μM (EC₅₀)

All DNA Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	EC₅₀	10.7 μM Compound: 3b	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay	[PMID: 31757526]
KG-1	EC₅₀	13 μM Compound: 3b	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay Cytotoxicity against human KG-1 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay	[PMID: 31757526]

In Vitro

DNMT-IN-1 (compound 3b) shows antiproliferative active with EC₅₀s of 13.0, 10.7 µM for KG1, HCT116 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

KG1, HCT116 cells
Concentration:

0-100 µM
Incubation Time:

72 h
Result:

Showed antiproliferative active with EC₅₀s of 13.0, 10.7 µM for KG1, HCT116 cells, respectively.

Chemical Information

CAS No. 2396691-28-2
Molecular Weight 393.15
Formula C₁₅H₉BrN₂O₆
SMILES

Br[C@@]1([N+]([O-])=O)[C@@H](C2=C([N+]([O-])=O)C=CC=C2)OC3=CC=CC=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pechalrieu D, et al. Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells. Eur J Med Chem. 2020 Jan 15;186:111829. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DNMT-IN-1

All DNA Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DNMT-IN-1 Related Classifications

HY-133030 Related Classifications