1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Iodophenpropit dihydrobromide

Iodophenpropit dihydrobromide 

Cat. No.: HY-107568
Handling Instructions

Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM).

For research use only. We do not sell to patients.

Iodophenpropit dihydrobromide Chemical Structure

Iodophenpropit dihydrobromide Chemical Structure

CAS No. : 145196-87-8

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Description

Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1].

IC50 & Target[1]

H3 Receptor

0.32 nM (Kd)

In Vitro

Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57±0.3 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg[4]
Dosage: 1 μg/kg
Administration: Administered through intramuscular (i.m.); b.i.d.; for 10 days
Result: Could influence a detectable antibody response to SRBC.
Molecular Weight

576.13

Formula

C₁₅H₂₁Br₂IN₄S

CAS No.

145196-87-8

SMILES

N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Iodophenpropit dihydrobromideHistamine ReceptorhistamineH3autoimmunediseaseimmunobiologyInhibitorinhibitorinhibit

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Iodophenpropit dihydrobromide
Cat. No.:
HY-107568
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