country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-154832

Copy Link Print Information

Cav 3.2 inhibitor 4

Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Ca_v3.2) inhibitor, with an IC₅₀ of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1416984-93-4
Formel: C₂₁H₃₂Cl₂N₄O₃
Molecular Weight:459.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cav 3.2 inhibitor 4 Chemical Structure

CAS. Nr.: 1416984-93-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>31.6 μM Compound: 21	Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human ERG expressed in CHO cells by IONWORKS assay Inhibition of human ERG expressed in CHO cells by IONWORKS assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
HEK293	IC₅₀	0.6 μM Compound: 21	Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay	[PMID: 23200256]
Oocyte	IC₅₀	0.6 μM Compound: 21	Inhibition of dog T-type calcium channel Cav3.2 expressed in oocytes Inhibition of dog T-type calcium channel Cav3.2 expressed in oocytes	[PMID: 23200256]

Chemical Information

CAS. Nr. 1416984-93-4
Molecular Weight 459.41
Formel C₂₁H₃₂Cl₂N₄O₃
SMILES

O=C(NCC1(CO)CCN(CCNC(NC(C)(C)C)=O)CC1)C2=CC(Cl)=CC(Cl)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Giordanetto F, et, al. Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor. Bioorg Med Chem Lett. 2013 Jan 1;23(1):119-24. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Cav 3.2 inhibitor 4

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cav 3.2 inhibitor 4 Related Classifications

HY-154832 Related Classifications