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Cat. No.: HY-154832

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Cav 3.2 inhibitor 4

Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Ca_v3.2) inhibitor, with an IC₅₀ of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation.

For research use only. We do not sell to patients.

CAS No.: 1416984-93-4
Formula: C₂₁H₃₂Cl₂N₄O₃
Molecular Weight:459.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cav 3.2 inhibitor 4 Chemical Structure

CAS No.: 1416984-93-4

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All Calcium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>31.6 μM Compound: 21	Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay Inhibition of calcium channel Cav1.2 (unknown origin) expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human ERG expressed in CHO cells by IONWORKS assay Inhibition of human ERG expressed in CHO cells by IONWORKS assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human HCN4 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human IKs channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human Kv4.3 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
CHO	IC₅₀	>33 μM Compound: 21	Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay Inhibition of human Nav1.5 channel expressed in CHO cells by IONWORKS patch clamp assay	[PMID: 23200256]
HEK293	IC₅₀	0.6 μM Compound: 21	Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay	[PMID: 23200256]
Oocyte	IC₅₀	0.6 μM Compound: 21	Inhibition of dog T-type calcium channel Cav3.2 expressed in oocytes Inhibition of dog T-type calcium channel Cav3.2 expressed in oocytes	[PMID: 23200256]

Chemical Information

CAS No. 1416984-93-4
Molecular Weight 459.41
Formula C₂₁H₃₂Cl₂N₄O₃
SMILES

O=C(NCC1(CO)CCN(CCNC(NC(C)(C)C)=O)CC1)C2=CC(Cl)=CC(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Giordanetto F, et, al. Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor. Bioorg Med Chem Lett. 2013 Jan 1;23(1):119-24. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Cav 3.2 inhibitor 4

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cav 3.2 inhibitor 4 Related Classifications

HY-154832 Related Classifications