1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. 1-Ethynylpyrene

1-Ethynylpyrene 

Cat. No.: HY-131452 Purity: 96.20%
Handling Instructions

1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1 with IC50s of 0.18, 0.32, and 0.04 μM, respectively.

For research use only. We do not sell to patients.

1-Ethynylpyrene Chemical Structure

1-Ethynylpyrene Chemical Structure

CAS No. : 34993-56-1

Size Price Stock Quantity
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 340 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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Description

1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1 with IC50s of 0.18, 0.32, and 0.04 μM, respectively[1].

In Vitro

1-Ethynylpyrene exhibits activity against P450 1A2, and 2B1 with Kis of 0.32 and 0.04 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

226.27

Formula

C18H10

CAS No.
SMILES

C#CC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.09 mg/mL (40.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4195 mL 22.0975 mL 44.1950 mL
5 mM 0.8839 mL 4.4195 mL 8.8390 mL
10 mM 0.4419 mL 2.2097 mL 4.4195 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.91 mg/mL (4.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.91 mg/mL (4.02 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References

Purity: 96.20%

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Product Name:
1-Ethynylpyrene
Cat. No.:
HY-131452
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