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DXd Antibody (YA897)

(Synonyms: Dxd, OQM5SD32BQ, UNII-OQM5SD32BQ, Exatecan derivative, Exatecan derivative for ADC)
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Based on 1 Customer Validation

DXd Antibody (YA897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DXd.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ELISA

  • Reactivity :

    Species independent

  • Formulation:

    Supplied in PBS, pH 7.4, containing 0.02% ProClin300 or PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for DXd Antibody (YA897)
  • DXd Antibody (YA897) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 0.01-2 µg/mL

Product Details

Description

DXd Antibody (YA897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DXd.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Species independent
Immunogen

DXd-KLH/Dxd-OVA

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3103045

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4, containing 0.02% ProClin300 or PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for DXd Antibody (YA897)
    Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD Antibody, the EC50 is 1.120 to 1.566 ng/mL.

Background

  • Function

    DXd is a Dxd (HY-13631D)：Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

  • Synonyms

    Dxd, OQM5SD32BQ, UNII-OQM5SD32BQ, Exatecan derivative, Exatecan derivative for ADC

DXd Antibody (YA897) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD Antibody, the EC50 is 1.120 to 1.566 ng/mL.

  • DXd Antibody (YA897) Product Image
    1/16
  • Experimental Validation Results for DXd Antibody (YA897)
  • DXd Antibody (YA897) Product Image
  • Experimental Validation Results for DXd Antibody (YA897)
    1/1
    MedchemExpress Validation
     Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD Antibody, the EC50 is 1.120 to 1.566 ng/mL.
  • Experimental Validation Results for DXd Antibody (YA897)
  • DXd Antibody (YA897) Product Image
    MedchemExpress Validation

    Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD Antibody, the EC50 is 1.120 to 1.566 ng/mL.

  • DXd Antibody (YA897) Product Image ELISA