L-Ascorbic acid-13C-2
Based on 1 Customer Validation
L-Ascorbic acid-13C-2 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1313730-17-4
- Formula: C513CH8O6
- Molecular Weight:177.12
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1313730-17-4
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Unlabeled Cas 50-81-7
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Appearance Solid
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Molecular Weight 177.12
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Formula C513CH8O6
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Color White to off-white
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SMILES
O[13C]([C@H](O1)[C@H](CO)O)=C(O)C1=O
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Synonyms
L-Ascorbate-13C-2; Vitamin C-13C-2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (564.59 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.;Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6459 mL | 28.2294 mL | 56.4589 mL | 141.1472 mL |
| 5 mM | 1.1292 mL | 5.6459 mL | 11.2918 mL | 28.2294 mL | |
| 10 mM | 0.5646 mL | 2.8229 mL | 5.6459 mL | 14.1147 mL | |
| 15 mM | 0.3764 mL | 1.8820 mL | 3.7639 mL | 9.4098 mL | |
| 20 mM | 0.2823 mL | 1.4115 mL | 2.8229 mL | 7.0574 mL | |
| 25 mM | 0.2258 mL | 1.1292 mL | 2.2584 mL | 5.6459 mL | |
| 30 mM | 0.1882 mL | 0.9410 mL | 1.8820 mL | 4.7049 mL | |
| 40 mM | 0.1411 mL | 0.7057 mL | 1.4115 mL | 3.5287 mL | |
| 50 mM | 0.1129 mL | 0.5646 mL | 1.1292 mL | 2.8229 mL | |
| 60 mM | 0.0941 mL | 0.4705 mL | 0.9410 mL | 2.3525 mL | |
| 80 mM | 0.0706 mL | 0.3529 mL | 0.7057 mL | 1.7643 mL | |
| 100 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4115 mL |
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