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Cat. No.: HY-172909

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RIPK3-IN-5

RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC₅₀ of 27 nM. RIPK3-IN-5 also inhibits necroptosis with an EC₅₀ of 0.45 μM.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₂F₂N₆
Molecular Weight:432.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

RIPK3-IN-5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC₅₀ of 27 nM. RIPK3-IN-5 also inhibits necroptosis with an EC₅₀ of 0.45 μM^[1].

All RIP kinase Isoforms :

Chemical Information

Molecular Weight 432.47
Formula C₂₄H₂₂F₂N₆
SMILES

CN1CCN(C2=CC=C(C3=CC4=NC=NC(NC5=C(F)C=CC=C5F)=C4C=C3)C=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Parry C W, et al. Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras[J]. Journal of Medicinal Chemistry, 2025, 68(9): 9129-9161.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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RIPK3-IN-5

All RIP kinase Isoforms