HPK1-IN-43
HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research.
For research use only. We do not sell to patients.
- Formula: C26H25F3N6O2
- Molecular Weight:510.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HPK1 0.32 nM (IC50) |
SLP-76 |
IL-2 |
IFN-γ |
HPK1-IN-43 (compound 9f) (0-100 nM, 1-18 h) inhibits phosphorylation of SLP76 in Jurkat and primary peripheral blood mononuclear cells (PBMC), with IC50 values of 147.9 nM and 131.8 nM, respectively. HPK1-IN-43 promotes IL-2 and IFN-γ production in PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 510.51
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Formula C26H25F3N6O2
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SMILES
O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-43 Related Classifications
HY-161335 Related Classifications
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